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American Journal of Epidemiology Vol. 143, No. 11: 1100-1106
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health

other

Sex Difference in High Density Lipoprotein Cholesterol in Six Countries

C. E. Davis1,, D. H. Williams1, R. G. Oganov2, S.-C. Tao3, S. L Rywik4, Y. Stein5 and J. A. Little6

1Department of Biostatistics, School of Public Health, University of North Carolina Chapel Hill, NC
2National Center for Preventive Medicine of the Russian Federation Moscow, Russia
3Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences Beijing, China
4Department of Cardiovascular Disease Epidemiology and Prevention, Cardinal Wyszynski National Institute of Cardiology Warsaw, Poland
5Hadassah Medical Organization, The Hebrew University Jerusalem, Israel
6Lipid Research Clinic, St.Michael's Hospital Toronto, Ontario, Canada

Reprint requests to Dr. C. E. Davis, Department of Biostatistics, Collaborative Studies Coordinating Center, Suite 203, 137 E. Franklin Street, Chapel Hill, NC 27514.

It is known that women have higher levels of high density lipoprotein (HDL) cholesterol than men. The authors examined the association between HDL cholesterol and biologic sex in 8, 631 women and 10, 690 men aged 45–54 years from six countries studied between 1972 and 1989. The variation in the sex difference for HDL cholesterol was significant; the smallest difference (0.06 mmol/liter) was seen in China and the largest (0.40 mmol/liter) in Canada. Adjustment for differences in body mass index, smoking, alcohol use, and heart rate reduced but did not eliminate the variability. The sex difference in HDL cholesterol levels, usually assumed to be due to biologic factors, differs across cultures and may be related to environmental factors. Am J Epidemiol 1996; 143: 1100–6.

alcohol drinking; body mass index; lipoproteins; HDL cholesterol; sex factors; smoking


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