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American Journal of Epidemiology Vol. 142, No. 9: 909-917
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health


other

Height and the Risk of Cardiovascular Disease in Women

Janet W. Rich-Edwards1,2,, JoAnn E. Manson2,3, Meir J. Stampfer1,3,4, Graham A. Colditz1,3, Walter C. Willett1,3,4, Bernard Rosner3,5, Frank E. Speizer3 and Charles H. Hennekens2,3

1Department of Epidemiology, Harvard University School of Public Health Boston, MA.
2Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Boston, MA
3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Boston, MA
4Department of Nutrition, Harvard School of Public Health Boston, MA
5Department of Biostatistics, Harvard School of Public Health Boston, MA

Reprint requests to Janet W. Rich-Edwards, Nurses' Health Study Office, Channing Laboratory, 180 Longwood Avenue, Boston, MA 02115.

Height has been inversely associated with coronary heart disease in several prospective studies in men, but data in women are sparse. The relation between height and cardiovascular disease was examined in 14 years of follow-up data from the Nurses' Health Study, a prospective cohort of 121,700 US female nurses aged 30–55 years in 1976. The relative risks associating height with coronary heart disease (nonfatal myocardial infarction (n = 1,000), fatal myocardial infarction (n = 304), confirmed angina (n = 1,343), or coronary revascularization (n = 901)) were estimated after adjustment for a large number of cardiovascular risk factors, including age and body mass index. Compared with the shortest women (≤61 inches (≤1.55 m)), the relative risk of coronary heart disease was 0.82 (95% confidence interval (Cl) 0.73–0.92) for women 62–63 inches (1.57–1.60 m) tall, 0.74 (95% Cl 0.65–0.85) for women 64 inches (1.63 m) tall, 0.79 (95% Cl 0.70–0.89) for women 65–66 inches (1.65–1.68 m) tall, and 0.73 (95% Cl 0.65–0.83) for women 67 or more inches (≥1.70 m) tall (P for trend < 0.0001). The inverse association was more pronounced for angina/coronary revascularization (P for trend < 0.0001; relative risk for 67 or more inches = 0.67 (95% Cl 0.58–0.78)) than for myocardial infarction (P for trend = 0.03; relative risk for 67 or more inches = 0.78 (95% Cl 0.64–0.95)). No trend was evident for height in relation to risk of stroke. These data support the hypothesis that height is inversely related to risk of coronary heart disease in women.

body height; cerebrovascular disorders; coronary disease; myocardial infarction; women


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