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American Journal of Epidemiology Vol. 142, No. 9: 1000-1006
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health

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Case-Cohort Analysis of Case-Coverage Studies of Vaccine Effectiveness

Lawrence H. Moulton1,2,, Mark C. Wolff3, George Brenneman1,4 and Mathuram Santosham1,5

1Department of International Health, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD
2Department of Biostatistics, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD
3The EMMES Corporation Potomac, MD
4Department of Maternal and Child Health, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD
5Department of Pediatrics, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD

Reprint requests to Dr. Lawrence H. Moulton, Department of International Health, The Johns Hopkins University School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD 21205.

Evaluation of vaccine field effectiveness may be performed by combining surveillance data on incident cases with an immunization coverage survey. Although many methods have been used for the analysis of studies of similar design, they are not always desirable or optimal. The authors discuss these approaches and propose use of a case-cohort analysis for such a study design when appropriate. The case-cohort analytic approach is illustrated with data from studies of a vaccine for Haemophilus influenzae type b (Hib) disease in children living on a southwestern Native American reservation during 1988–1993.

biometry; epidemiologic methods; follow-up studies; research design; statistics; vaccination


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L. H Moulton, S.-e. Chung, J. Croll, R. Reid, R. C Weatherholtz, and M. Santosham
Estimation of the indirect effect of Haemophilus influenzae type b conjugate vaccine in an American Indian population
Int. J. Epidemiol., August 1, 2000; 29(4): 753 - 756.
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