American Journal of Epidemiology Vol. 142, No. 7: 759-764
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health
other |
Impaired Immune Response to Natural Infection as a Correlate of Vaccine Failure in a Field Trial of Killed Oral Cholera Vaccines
1International Centre for Diarrheoal Disease Research Bangladesh, Dhaka, Bangladesh.
2National Institute of Child Health and Human Development Bethesda, MD.
3The Johns Hopkins School of Public Health Baltimore, MD.
4Centers for Disease Control and Prevention Atlanta, GA.
5University of Goteborg Goteborg, Sweden.
In a field trial carried out in 1985 in Matlab, Bangladesh, the authors evaluated whether subjects who developed Vibrio cholerae 01 infections during the first year after earlier receipt of B subunit-killed whole cell (BS-WC) or killed whole cell-only (WC) oral cholera vaccines exhibited deficient serum vibriocidal immune responses to these infections. After severe V. cholerae 01 infections (n = 70) in subjects < 5 years of age, the age group in which both vaccines were efficacious, a 6.5 geometric mean-fold rise of serum vibriocidal antibodies was observed among vaccinees, compared with an 18.6 geometric mean-fold rise in placeborecipients (p > 0.01). Depressions of serum vibriocidal responses among vaccinees were even more marked after asymptomatic infections (n = 30): a 1.1 geometric mean-fold rise in vaccinees versus a 5.9 geometric mean-fold rise in placebo-recipients (p < 0.01). The authors conclude that subjects who failed to be protected by BS-WC and WC, despite being in the age group for which these vaccines were protective, exhibited poor immune responses even to the vigorous stimulus of natural infection. These findings raise the possibility that immune hyporesponsiveness may limit the potential efficacy attainable by cholera vaccines in populations with endemic cholera. Am J Epidemiol 1995;142:759–64.
cholera;; cholera vaccine;; seroepidemiologic methods
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Ahmed, A. Lundgren, M. Arifuzzaman, F. Qadri, S. Teneberg, and A.-M. Svennerholm Children with the Le(a+b-) Blood Group Have Increased Susceptibility to Diarrhea Caused by Enterotoxigenic Escherichia coli Expressing Colonization Factor I Group Fimbriae Infect. Immun., May 1, 2009; 77(5): 2059 - 2064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Qadri, A. Saha, T. Ahmed, A. Al Tarique, Y. A. Begum, and A.-M. Svennerholm Disease Burden Due to Enterotoxigenic Escherichia coli in the First 2 Years of Life in an Urban Community in Bangladesh Infect. Immun., August 1, 2007; 75(8): 3961 - 3968. [Abstract] [Full Text] [PDF]
|
|