American Journal of Epidemiology Vol. 142, No. 1: 23-35
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Air Pollution and Hospital Admissions for Cardiovascular Disease in Detroit, Michigan
1Environmental Epidemiology Program, Harvard School of Public Health Boston, MA
2Department of Epidemiology, Medical College of Wisconsin Milwaukee, WI.
In the December 1952 smog disaster in London, a substantial increase in mortality was closely associated with the increase in air pollution. Deaths from cardiovascular causes were elevated as well as respiratory deaths. The increase was greatest in the elderly. Hospital admissions were increased for both respiratory and cardiovascular diseases. Since then, many studies have reported associations between lower concentrations of air pollution and daily mortality. Little attention has been paid to the question of hospital admissions for cardiovascular illness, however. This study examined the association between air pollution and cardiovascular hospital admissions for persons aged 65 years and older in the Detroit, Michigan, metropolitan area during the years 1986–1989. After controlling for seasonal and other long-term temporal trends, temperature, and dew point temperature, the particulate matter with an aerodiameter of 
10 µm (PM10) was associated with daily admissions for ischemic heart disease (relative nsk (RR) = 1.018, 95% confidence interval (Cl) 1.005–1.032 for an interquartile range (32 µg/m3) increase in pollution). SO2, CO, and ozone made no independent contribution to ischemic heart disease admissions. Both PM10 (RR = 1.024, 95% Cl 1.004–1.044) and CO (RR = 1.022, 95% Cl 1.010–1.034 for an interquartile range (1.28 ppm) increase in pollution) showed independent associations with heart failure admissions. These results were robust to alternate methods of estimation and weather control. Am J Epidemiol 1995; 142:23–35.
aerosols;; air pollution;; carbon monoxide;; heart diseases;; hospitalization;; weather.
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|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
R. T. Burnett, M. Smith-Doiron, D. Stieb, M. E. Raizenne, J. R. Brook, R. E. Dales, J. A. Leech, S. Cakmak, and D. Krewski Association between Ozone and Hospitalization for Acute Respiratory Diseases in Children Less than 2 Years of Age Am. J. Epidemiol., March 1, 2001; 153(5): 444 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Ballester, J M Tenias, and S Perez-Hoyos Air pollution and emergency hospital admissions for cardiovascular diseases in Valencia, Spain J Epidemiol Community Health, January 1, 2001; 55(1): 57 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Pekkanen, E J Brunner, H R Anderson, P Tiittanen, and R W Atkinson Daily concentrations of air pollution and plasma fibrinogen in London Occup. Environ. Med., December 1, 2000; 57(12): 818 - 822. [Abstract] [Full Text]
|
|
|
|
|
|
S. Y. Gardner, J. R. Lehmann, and D. L. Costa Oil Fly Ash-Induced Elevation of Plasma Fibrinogen Levels in Rats Toxicol. Sci., July 1, 2000; 56(1): 175 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Thom, D. Fisher, Y. A. Xu, K. Notarfrancesco, and H. Ischiropoulos Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide PNAS, February 1, 2000; 97(3): 1305 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Dye, K. B. Adler, J. H. Richards, and K. L. Dreher Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression Am J Physiol Lung Cell Mol Physiol, September 1, 1999; 277(3): L498 - L510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. ZEMP, S. ELSASSER, C. SCHINDLER, N. KUNZLI, A. P. PERRUCHOUD, G. DOMENIGHETTI, T. MEDICI, U. ACKERMANN-LIEBRICH, P. LEUENBERGER, C. MONN, et al. Long-Term Ambient Air Pollution and Respiratory Symptoms in Adults (SAPALDIA Study) Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): 1257 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. POPE III, D. W. DOCKERY, R. E. KANNER, G. M. VILLEGAS, and J. SCHWARTZ Oxygen Saturation, Pulse Rate, and Particulate Air Pollution . A Daily Time-Series Panel Study Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 365 - 372. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Kennedy, A. J. Ghio, W. Reed, J. Samet, J. Zagorski, J. Quay, J. Carter, L. Dailey, J. R. Hoidal, and R. B. Devlin Copper-dependent Inflammation and Nuclear Factor-kappa B Activation by Particulate Air Pollution Am. J. Respir. Cell Mol. Biol., September 1, 1998; 19(3): 366 - 378. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Dye, K. B. Adler, J. H. Richards, and K. L. Dreher Epithelial Injury Induced by Exposure to Residual Oil Fly-Ash Particles: Role of Reactive Oxygen Species? Am. J. Respir. Cell Mol. Biol., November 1, 1997; 17(5): 625 - 633. [Abstract] [Full Text]
|
|