American Journal of Epidemiology Vol. 141, No. 9: 815-821
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health
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Lipoprotein(a) Levels in the Japanese Population: Influence of Age and Sex, and Relation to Atherosclerotic Risk Factors: The Jichi Medical School Cohort Study
1Department of Community and Family Medicine, Jichl Medical School Tochigi, Japan.
2Department of Internal Medicine, Tako Central Hospital Chiba, Japan
3Takasu National Health Insurance Clinic Gifu, Japan
4Department of Internal Medicine, Wara National Health Insurance Hospital Gifu, Japan
5Department of Internal Medicine, Awaji-Hokutan Public Clinic Hyogo, Japan
6Department of Internal Medicine, Akaike Hospital Fukuoka, Japan
7Department of Public Health, Jichi Medical School Tochigi, Japan
Reprint requests to Dr. Naoki Nago, Department of Community and Family Medicine, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, 329-04 Japan.
The authors studied the distribution of lipoprotein(a)(Lp(a)) levels with stratification for age and sex, as well as the relation between Lp(a) and atherosclerotic risk factors in a large Japanese population between 1992 and 1993. The subjects were 1,235 males and 1,762 females over 30 years old. Lp(a) was measured by an enzyme-linked immunosorbent assay. Lp(a) levels were higher in females than in males. The increase in Lp(a) with age was statistically significant, and the proportion of subjects with Lp(a) levels <30 mg/dl also Increased with age. In the obese subjects (body mass index (BMI) (kg/m2) <26), Lp(a) levels were lower than in the non-obese subjects (BMI
26)(
> 0.01 in males; > 0.05 in females). Male alcohol drinkers had lower Lp(a) levels than nondrinkers ( > 0.05). Age, low density lipoprotein subtracting Lp(a) cholesterol [Lp(a) × 0.3], and fibrinogen level were all positively correlated with Lp(a) in both sexes. Alcohol consumption (g/day) and triglycerides were inversely correlated with Lp(a) in males, while total cholesterol subtracting Lp(a) cholesterol [Lp(a) × 0.3], high density lipoprotein, and factor VII were positively correlated in females. Multiple logistic regression analysis showed that triglycerides in males and BMI and fibrinogen in females were significant independent variables. The authors conclude that Lp(a) level is affected by various factors, such as alcohol drinking, BMI, sex, and age, and is not only correlated with lipid levels but also with hemostatic factors such as fibrinogen and factor VII. Am J Epidemiol 1995;141:815–21.
age factors; lipoprotein(a); risk factors; sex
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