American Journal of Epidemiology Vol. 141, No. 8: 719-723
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
No Association between Serum Ferritin and Asymptomatic Carotid Atherosclerosis
The Atherosclerosis Risk in Communities (ARIC) Study
1Mayo Graduate School of Medicine Rochester, MN
2Division of Epidemiology, School of Public Health, University of Minnesota Minneapolis, MN
3ARIC Ultrasound Reading Center Winston-Salem, NC
4Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota Minneapolis, MN
Reprint requests to Dr. Aaron Folsom, Division of Epidemiology, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454-1015.
A possible association between body iron stores, measured as serum ferritin, and carotid arterial intimamedia thickening was investigated in the Atherosclerosis Risk in Communities Study during 1990–1992 using a matched case-control design. For a 143µg/liter greater serum ferritin concentration (the interquartile range), the odds ratio for cases with carotid intima-media thickening versus controls was 1.12 (95% confidence interval 0.97–1.30). However, there was no association (odds ratio = 1.00) after adjusting for major cardio vascular risk factors. This analysis of carotid arterial intima-media thickening, a measure of early atherosclerosis, in relation to serum ferritin does not support the hypothesis that increased body iron stores increase the risk of atherosclerotic cardiovascular disease. Am J Epidemiol 1995;141:719–23.
atherosclerosis;; cardiovascular diseases;; ferritin;; iron.
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