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American Journal of Epidemiology Vol. 141, No. 8: 716-718
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health

article-commentary

Hypothesis: Low Serum Cholesterol, Suicide, and lnterleukin-2

Jyrki Penttinen

FromThe Kuopio Regional Institute of Occupational Health P.O. Box 93, FIN-70701 Kuopio, Finland

Reprint requests to Dr.J.Penttinen at this address.

An excess mortality for violence (suicides and injuries) has been observed following the use of cholesterollowering drugs. It has been suggested that low cholesterol is associated with depression by modifying the serotonin metabolism. In this paper, a new hypothesis concerning the association among serum lipids, depression, and atherosclerosis is proposed. The hypothesis is based on epidemiologic evidence concerning serum lipids, depression, violent deaths, and atherosclerosis. It is also based on previous results concerning a cytokine, interieukin-2. Recent observations indicate that interleukin-2 has an important role in lipid metabolism, depression, and atherosclerosis. Am J Epidemiol 1995;141:716–18.

atherosclerosis;; cholesterol;; interieukin-2;; suicide.


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