American Journal of Epidemiology Vol. 141, No. 4: 322-334
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Diet and Nuclear Lens Opacities
1Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School Madison, WI
2Department of Preventive Medicine, University of Wisconsin Madison, WI
Reprint requests to Dr. Julie A. Mares-Penman, Dept. of Ophthaimology and Visual Sciences, University of Wisconsin-Madison, 610 N. Walnut Street, 405 WARF, Madison, WI 53705-2397
Relations between diet and nuclear opacities in the lens of the eye were investigated in a population-based cohort of middle-aged and older adults who lived in Beaver Dam, Wisconsin. Nuclear sclerosis was assessed from photographs of the lens taken during 1988–1990 in 1,919 persons in the Beaver Dam Eye Study. Diets in the past (1978–1980) were assessed retrospectively with the use of a food frequency questionnaire in home interviews. Relations with intake of foods and nutrients were evaluated using logistic regression analyses. In men, after controlling for age, smoking, and heavy drinking, intakes of numerous nutrients in the highest versus lowest quintile were associated with 40-50 percent reduced odds of more severe nuclear sclerosis. Relations with some nutnents (vitamins A, C, and E, riboflavin, thiamin, niacin) were at least partly explained by previously identified inverse associations with multivitamin use. Relations with other nutrients (folate, 
-carotene, and dietary fiber) appeared to reflect associations with intake of foods, particularly vegetables. Inverse associations with individual nutrients and foods were often weaker or nonexistent in women. These data indicate that the intake of vitamin supplements (in men and women) and certain foods (particularly in men) may explain associations of several nutrients with risk for nuclear sclerosis.
cataract; diet; lens diseases; retrospective studies
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. M. Moeller, R. Voland, L. Tinker, B. A. Blodi, M. L. Klein, K. M. Gehrs, E. J. Johnson, D. M. Snodderly, R. B. Wallace, R. J. Chappell, et al. Associations Between Age-Related Nuclear Cataract and Lutein and Zeaxanthin in the Diet and Serum in the Carotenoids in the Age-Related Eye Disease Study (CAREDS), an Ancillary Study of the Women's Health Initiative Arch Ophthalmol, March 1, 2008; 126(3): 354 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Christen, S. Liu, R. J. Glynn, J. M. Gaziano, and J. E. Buring Dietary Carotenoids, Vitamins C and E, and Risk of Cataract in Women: A Prospective Study Arch Ophthalmol, January 1, 2008; 126(1): 102 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tan, J. J. Wang, V. Flood, S. Kaushik, A. Barclay, J. Brand-Miller, and P. Mitchell Carbohydrate nutrition, glycemic index, and the 10-y incidence of cataract Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1502 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lu, A. Taylor, L. T. Chylack Jr, G. Rogers, S. E. Hankinson, W. C. Willett, and P. F. Jacques Dietary Linolenic Acid Intake Is Positively Associated with Five-Year Change in Eye Lens Nuclear Density J. Am. Coll. Nutr., April 1, 2007; 26(2): 133 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D C Gritz, M Srinivasan, S D Smith, U Kim, T M Lietman, J H Wilkins, B Priyadharshini, R K John, S Aravind, N V Prajna, et al. The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India Br. J. Ophthalmol., July 1, 2006; 90(7): 847 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Chiu, R. C Milton, G. Gensler, and A. Taylor Dietary carbohydrate intake and glycemic index in relation to cortical and nuclear lens opacities in the Age-Related Eye Disease Study Am. J. Clinical Nutrition, May 1, 2006; 83(5): 1177 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Q Pham and R. Plakogiannis Vitamin E Supplementation in Alzheimer's Disease, Parkinson's Disease, Tardive Dyskinesia, and Cataract: Part 2 Ann. Pharmacother., December 1, 2005; 39(12): 2065 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Chiu, M. S Morris, G. Rogers, P. F Jacques, L. T Chylack Jr, W. Tung, S. E Hankinson, W. C Willett, and A. Taylor Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1411 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G Christen, S. Liu, D. A Schaumberg, and J. E Buring Fruit and vegetable intake and the risk of cataract in women Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1417 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lu, E. Cho, A. Taylor, S. E. Hankinson, W. C. Willett, and P. F. Jacques Prospective Study of Dietary Fat and Risk of Cataract Extraction among US Women Am. J. Epidemiol., May 15, 2005; 161(10): 948 - 959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lu, A. Taylor, L. T Chylack Jr, G. Rogers, S. E Hankinson, W. C Willett, and P. F Jacques Dietary fat intake and early age-related lens opacities Am. J. Clinical Nutrition, April 1, 2005; 81(4): 773 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Jacques, A. Taylor, S. Moeller, S. E. Hankinson, G. Rogers, W. Tung, J. Ludovico, W. C. Willett, and L. T. Chylack Jr Long-term Nutrient Intake and 5-Year Change in Nuclear Lens Opacities Arch Ophthalmol, April 1, 2005; 123(4): 517 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Delcourt, A.-M. Dupuy, I. Carriere, A. Lacroux, J.-P. Cristol, and for the Pathologies Oculaires Liees a l'Age (POLA) Albumin and Transthyretin as Risk Factors for Cataract: The POLA Study Arch Ophthalmol, February 1, 2005; 123(2): 225 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Moeller, A. Taylor, K. L. Tucker, M. L. McCullough, L. T. Chylack Jr, S. E. Hankinson, W. C. Willett, and P. F. Jacques Overall Adherence to the Dietary Guidelines for Americans Is Associated with Reduced Prevalence of Early Age-Related Nuclear Lens Opacities in Women J. Nutr., July 1, 2004; 134(7): 1812 - 1819. [Abstract] [Full Text]
|
|
|
|
|
|
W. G. Christen, J. E. Manson, R. J. Glynn, J. M. Gaziano, R. D. Sperduto, J. E. Buring, and C. H. Hennekens A Randomized Trial of Beta Carotene and Age-Related Cataract in US Physicians Arch Ophthalmol, March 1, 2003; 121(3): 372 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. J. M. Berendschot, W. M. R. Broekmans, I. A. A. Klopping-Ketelaars, A. F. M. Kardinaal, G. van Poppel, and D. van Norren Lens Aging in Relation to Nutritional Determinants and Possible Risk Factors for Age-Related Cataract Arch Ophthalmol, December 1, 2002; 120(12): 1732 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Klein, B. E. K. Klein, T. Y. Wong, S. C. Tomany, and K. J. Cruickshanks The Association of Cataract and Cataract Surgery With the Long-term Incidence of Age-Related Maculopathy: The Beaver Dam Eye Study Arch Ophthalmol, November 1, 2002; 120(11): 1551 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Valero, A. E. Fletcher, B. L. De Stavola, J. Vioque, and V. C. Alepuz Vitamin C Is Associated with Reduced Risk of Cataract in a Mediterranean Population J. Nutr., June 1, 2002; 132(6): 1299 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Taylor, P. F Jacques, L. T Chylack Jr, S. E Hankinson, P. M Khu, G. Rogers, J. Friend, W. Tung, J. K Wolfe, N. Padhye, et al. Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities Am. J. Clinical Nutrition, March 1, 2002; 75(3): 540 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Mares-Perlman, A. E. Millen, T. L. Ficek, and S. E. Hankinson The Body of Evidence to Support a Protective Role for Lutein and Zeaxanthin in Delaying Chronic Disease. Overview J. Nutr., March 1, 2002; 132(3): 518S - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Weintraub, W. C. Willett, B. Rosner, G. A. Colditz, J. M. Seddon, and S. E. Hankinson Smoking Cessation and Risk of Cataract Extraction among US Women and Men Am. J. Epidemiol., January 1, 2002; 155(1): 72 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Age-Related Eye Disease Study Research Group A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E and Beta Carotene for Age-Related Cataract and Vision Loss: AREDS Report No. 9 Arch Ophthalmol, October 1, 2001; 119(10): 1439 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Mares-Perlman, B. J. Lyle, R. Klein, A. I. Fisher, W. E. Brady, G. M. VandenLangenberg, J. N. Trabulsi, and M. Palta Vitamin Supplement Use and Incident Cataracts in a Population-Based Study Arch Ophthalmol, November 1, 2000; 118(11): 1556 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Moeller, P. F. Jacques, and J. B. Blumberg The Potential Role of Dietary Xanthophylls in Cataract and Age-Related Macular Degeneration J. Am. Coll. Nutr., October 1, 2000; 19(90005): 522S - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Mares-Perlman Too soon for lutein supplements Am. J. Clinical Nutrition, October 1, 1999; 70(4): 431 - 432. [Full Text] [PDF]
|
|
|
|
|
|
L. Chasan-Taber, W. C Willett, J. M Seddon, M. J Stampfer, B. Rosner, G. A Colditz, F. E Speizer, and S. E Hankinson A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women Am. J. Clinical Nutrition, October 1, 1999; 70(4): 509 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Brown, E. B Rimm, J. M Seddon, E. L Giovannucci, L. Chasan-Taber, D. Spiegelman, W. C Willett, and S. E Hankinson A prospective study of carotenoid intake and risk of cataract extraction in US men Am. J. Clinical Nutrition, October 1, 1999; 70(4): 517 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J Lyle, J. A Mares-Perlman, B. E. Klein, R. Klein, M. Palta, P. E Bowen, and J. L Greger Serum carotenoids and tocopherols and incidence of age-related nuclear cataract Am. J. Clinical Nutrition, February 1, 1999; 69(2): 272 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Klein, B. E. K. Klein, S. C. Jensen, and K. J. Cruickshanks The Relationship of Ocular Factors to the Incidence and Progression of Age-Related Maculopathy Arch Ophthalmol, April 1, 1998; 116(4): 506 - 513. [Abstract] [Full Text] [PDF]
|
|