American Journal of Epidemiology Vol. 140, No. 9: 821-829
Copyright © 1994 by The Johns Hopkins University School of Hygiene and Public Health
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Low-level Lead Exposure and Renal Function in the Normative Aging Study
1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School Boston, MA
2Occupational Health Program, Department of Environmental Health, Harvard School of Public Health Boston, MA
3Outpatient Clinic, Department of Veterans Affairs Boston, MA
Reprint requests to Dr. Marinelle Payton, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115
Occupational and environmental lead exposure has been associated with significant impairment in renal function. The authors studied the cross-sectional relation between creatinine clearance and blood lead concentration in a population of 744 menparticipating in the Normative Aging Study of the Department of Veterans Affairs between July 1988 and April 1991. These men, aged 43–90 years, were recruited from communities in the Greater Boston, Massachusetts, area and were selected without regard to lead exposure. The mean values for blood lead concentration and creatinine clearance rate were 8.1 µg/dl (standard deviation, 3.9 µg/dl) and 88.2 ml/minute(standard deviation, 22.0 ml/minute), respectively. Independent relations of creatinine clearance to blood lead were assessed by multivariate linear regression analysis, with adjustment for various potential confounders. In multivariate linear regression models, the rate of creatinine clearance was significantly and negatively associated with increasing levels of blood lead, even after adjustment for age, body mass index, and use of diuretic and analgesic medications (the ß-coefficient for In blood lead measured in µg[µg/dl] was –0.030; standard error = 0.014, p = 0.037). A rise in In blood lead of 10.0 µg/dl was associated with a decrease in the In creatinine clearance rate of 10.4 mI/minute. These results support the hypothesis that exposure to low-level environ mental lead correlates with a significant decrement in renal function. Am J Epidemiol 1994;1 40:821–9.
creatinine; kidney; lead
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