American Journal of Epidemiology Vol. 140, No. 6: 510-517
Copyright © 1994 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Adult Leukemia Risk and Personal Appliance Use: A Preliminary Study
From the Pacific Northwest Laboratory, Richland, WA, and Battelle Seattle Research Center, Seattle, WA
Reprint requests to Dr. Richard H. Lovely, Battelle Seattle Research Center, N.E. 41st. Street, Seattle, WA 98105
The hypothesis that use of personal electric appliances may be associated with increased risk of acute nonlymphocytic leukemia in adults was tested using interview data from a previously completed case-control study of 114 cases and 133 controls conducted between 1981 and 1984. Cases were obtained from a population-based cancer registry in western Washington state, and controls were obtained from the same area by random digit dialing. Of 32 electrical home appliances for which data on use were available for adult acute nonlymphocytic leukemia cases and controls, three motor-driven personal appliances (electric razors, hair dryers, and massage units) were selected a priori because their use represents exposure to higher peak magnetic fields than that from most other home appliances. When compared on an "ever used" versus "never used" basis, use of one or more of these appliances was not associated with increased risk of leukemia in the population studied (odds ratio (OR) = 0.71, 95% confidence interval (Cl) 0.41–1.24). When the appliances were considered individually, massage units were more likely to have been used by cases than by controls (OR = 3.00, 95% Cl 1.43–6.32), while hair dryers were more likely to have been used by controls than cases (OR = 0.38, 95% Cl 0.22–0.66). There was a nonsignificant tendency for electric razor use to differentiate the cases from controls (OR = 1.33, 95% Cl 0.80–2.23). When reported daily time of use was stratified, there was no overall increased risk with increased time of use except for electric razors (p < 0.05). In addition to the analysis of appliance use data from the case-control study, the authors obtained several models of these motor-driven personal appliances and characterized the magnetic fields they produce. Magnetic field flux density, or the B-field, and spectral measurements showed that partial body exposure from such appliances may exceed 0.5 mTesla (root mean squared) at rates-of-change exceeding 10 Tesla/sec. These epidemiologic data must be interpreted cautiously because the number of cases is limited and because of proxy reporting of appliance use for deceased cases. Nevertheless, the authors believe these data indicate that peak magnetic field exposure from personal appliances warrants further investigation as a possible risk factor for acute nonlyrnphocytlc leukemia in adults.
adult; electromagnetic fields; household products; leukemia; nonlymphocytic; acute