American Journal of Epidemiology Vol. 140, No. 4: 340-349
Copyright © 1994 by The Johns Hopkins University School of Hygiene and Public Health
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Sinonasal Cancer and Wood Dust Exposure: Results from a Case-Control Study
1 Unité 88, INSERM, 91 boulevard del'Hôpital, 75013 Paris, France
2Faculté de Médecine, Université de Montréal CP 6128 Succ. A, Montreal, Quebec H3C 3J7, Canada
3Institut Curie 26 rue d'Ulm, 75231 Paris Cedex 05, France
Reprint requests to Dr. Annette Leclerc, Unité 88 INSEAM, 91 boulevard de l'Hôpital, 75013 Paris, France
A case-control study of occupational risk factors for sinonasal cancer was conducted in France in 1986–1988. The study included 207 histologically confirmed cases and 409 controls. Among the male cases were 59 men with squamous cell carcinoma and 82 with adenocarcinoma. The risk of sinonasal cancer in relation to wood dust exposure was studied in these two groups. The analysis was based on a case-by-case assessment of exposure by an industrial hygienist. Hardwood and softwood were distinguished. An approximate twofold increase in risk for squamous cell carcinomas was observed for cases whose first exposure to either hardwood or softwood occurred before 1945; how ever, the two types of exposure were highly correlated. An exposure to wood dust—from either hardwood alone or hardwood and other kinds of wood—was found for all but two of the 82 male cases with adenocarcinoma. The effects of different elements of exposure to hardwood (duration, level, period) were studied in detail with a logistic model. Two components of exposure—duration and average level—contributed independently to the overall very elevated risk. Additional exposure to wood other than hardwood did not increase the risk.
case-control studies; nose; occupational exposure; paranasal sinus neoplasms; wood
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