American Journal of Epidemiology Vol. 140, No. 2: 132-147
Copyright © 1994 by The Johns Hopkins University School of Hygiene and Public Health
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Determinants of Plasma Vitamins and Lipids: The Working Well Study
1Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School Worcester, MA
2Division of Epidemiology and Control, Dana-Farber Cancer Institute Boston, MA
3Department of Clinical Laboratory Sciences, College of Health Professions, University of Massachusetts Lowell, MA
4Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, MA
Reprint requests to Dr. James R. Hebert, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655
This study was conducted to assess the determinants of plasma concentrations of 
-tocopherol, ß-carotene, retinol, and cholesterol fractions in a randomly selected subset of 203 workers participating in a worksite-based health intervention trial. Workers were from four companies in eastern and central Massachusetts, and all completed an 84-item semiquantitative food frequency questionnaire as part of baseline (preintervention) self-assessment instruments. At the time of fasting blood sampling, each participant also completed a short screening questionnaire for assessment of changes in dietary habits and tobacco exposure and for collection of data on use of vitamins and nutritional supplements. On the basis of the self-reported data, the authors found that they could explain 35% of the variability in plasma ß-carotene, 73% of the variability in -tocopherol, 36% of the variability in retinol, and 19% of the variability in cholesterol. Plasma ß-carotene levels appeared to be affected by the use of supplements that did not contain carotene, indicating a ß-carotene sparing capability of other agents contained in these preparations. Plasma -tocopherol levels were not similarly affected. These results compare favorably with those from studies that used more intensive dietary assessment techniques as the comparison criterion. Results are discussed in terms of implications for use of self-reported data in epidemiologic study analyses.
carotene; cholesterol; diet; plasma; vitamin A; vitamin E
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