American Journal of Epidemiology Vol. 138, No. 12: 1023-1036
Copyright © 1993 by The Johns Hopkins University School of Hygiene and Public Health
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Plasma Fibrinogen: Levels and Correlates in Young Adults
1Division of Epidemiology, School of Public Health, University of Minnesota Minneapolis, MN.
2Department of Medicine, Division of General Internal Medicine, University of Minnesota Minneapolis, MN.
3CARDIA Coordinating Center, University of Alabama at Birmingham Birmingham, AL.
4Northwestern University Medical School Chicago, IL.
5Mediantic Research Institute Washington, DC.
6Vermont Thrombosis Center, University of Vermont Burlington, VT.
Reprint requests to Dr. Aaron R Folsom, Division of Epidemiology, School of Public Health, University of Minnesota, Suite 300,1300 South Second Street, Minneapolis, MN 55454.
Sufficient evidence exists that plasma fibrinogen is a risk factor for cardiovascular disease to prompt a search for fibrinogen determinants. The authors measured fibnnogen in 4, 193 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study with three objectives: to describe fibrinogen levels in young adults, to determine if correlates of fibrinogen in older adults apply to younger adults, and to examine several additional hypothesized correlates. Fibrinogen (overall mean ± standard deviation = 263 ± 57 mg/dl) was greater in women than in men and in blacks than in whites; it was associated positively with cigarette smoking, body mass index, low density lipoprotein cholesterol, triglycerides, and blood pressure, and negatively with physical activity, high density lipoprotein cholesterol, and ethanol intake. Socioeconomic stress indicators and negative personality traits hypothesized as being associated with fibrinogen, possibly through adrenergic mechanisms, proved weak correlates. Parental history of diabetes was correlated positively with fibrinogen, in part because those with a positive parental history had greater body mass. Diabetes mellitus, lipoprotein(a), left ventricular mass, and oral contraceptive use were also positively correlated with fibrinogen concentration. Thus, even in young adults, fibrinogen is associated positively with most risk factors for atherosclerotic cardiovascular disease. This has implications for the role of fibrinogen as a risk factor and, potentially, for cardiovascular disease prevention.
blood coagulation factors; coronary disease; fibrinogen
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