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American Journal of Epidemiology Vol. 137, No. 2: 201-206
Copyright © 1993 by The Johns Hopkins University School of Hygiene and Public Health

research-article

A Prospective Study of Dehydroepiandrosterone Sulfate (DHEAS) and Bone Mineral Density in Older Men and Women

Elizabeth Barrett-Connor, Donna Kritz-Silverstein and Sharon L. Edelstein

From the Department of Community and Family Medicine, University of California San Diego, La Jolla, CA

Reprint requests to Dr. Elizabeth Barrett-Connor, Department of Community and Family Medicine (0607), University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0607

The purpose of this study was to prospectively examine the relation of dehydroepiandrosterone sulfate (DHEAS) to bone mineral density in a community-based sample of 260 men and 162 women who were residents of Rancho Bernardo, California. DHEAS levels had been measured in plasma obtained in 1972–1974 when the men were 50–74 years of age and the women were 55–74. In 1988–1991, bone mineral density was measured at the lumbar spine and hip using dual x-ray absorptiometry, and at the mid-radius and ultradistal radius using single photon absorptiometry. Among men, there was a significant decrease in DHEAS levels and bone mineral density at the hip, ultradistal radius, and midshaft radius with increasing age. However, for both men and women, there was no significant association of DHEAS levels with bone mineral density at any site, both before and after adjustment for age, obesity, cigarette smoking, and use of antihypertensive medications. These data do not support the hypothesis of DHEAS having a causal role in senile osteoporosis. Am J Epidemiol 1993;137:201–6.

bone density; dehydroepiandrosterone; geriatrics; osteoporosis; prospective studies


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