American Journal of Epidemiology Vol. 137, No. 2: 155-165
Copyright © 1993 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
A Population-based Case-Control Study of Dietary Factors and Endometrial Cancer in Shanghai, People's Republic of China
1Department of Epidemiology, Shanghai Cancer Institute Shanghai, People's Republic of China
2Division of Epidemiology, Columbia University New York, NY
3Epidemiology and Biostatistics Program, National Cancer Institute Bethesda, MD
Reprint requests to Dr. Louise A. Brinton, Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892
The relation between diet and endometrial cancer was examined in a population-based case-control study conducted in Shanghai, People's Republic of China, between 1988 and 1990, involving interviews with 268 cases and 268 controls aged 18–74 years. The subjects' usual dietary intake of 63 major foods during the previous 10 years (disregarding any recent changes) was measured by means of a structured quantitative food questionnaire. Although women in the highest quartile of total caloric intake had a 2.1-fold increased risk of endometrial cancer, risk varied according to the source of calories. The highest quartiles of caloric intake from fat and protein were associated with odds ratios of 3.9 and 3.1, respectively, while calories from carbohydrates, the major contributor of total calories in this population, were not related to risk. The association of fat and protein with endometrial cancer risk was confined to foods of animal origin in the diet. After adjustment for age, body mass index (weight (kg)/height (m)2), and number of pregnancies, odds ratios were 3.5 (95% confidence interval (CI) 2.0–6.0) and 3.0 (95% Cl 1.7–5.1) for women in the highest quartiles of intake of animal fat and animal protein, respectively. Food group analyses showed a similar pattern, with high consumption of meat, eggs, and fresh fish being associated with elevated risks. After adjustment for total calories, no significant association of risk was found with intake of vegetables or dark green/yellow vegetables, or with estimated carotene intake, although fruit and allium vegetables were associated with some reduction in risk. These results suggest that diets rich in animal fat and animal protein may play an important role in the etiology of endometrial cancer. Am J Epidemiol 1993;137:155–65.
case-control studies; dietary fats; endometrium; nutrition; risk factors; uterine neoplasms
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Yeh, K. B. Moysich, V. Jayaprakash, K. J. Rodabaugh, S. Graham, J. R. Brasure, and S. E. McCann Higher Intakes of Vegetables and Vegetable-Related Nutrients Are Associated with Lower Endometrial Cancer Risks J. Nutr., February 1, 2009; 139(2): 317 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Friberg and A. Wolk Long-term Alcohol Consumption and Risk of Endometrial Cancer Incidence: A Prospective Cohort Study Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 355 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. V Bandera, L. H Kushi, D. F Moore, D. M Gifkins, and M. L McCullough Association between dietary fiber and endometrial cancer: a dose-response meta-analysis Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1730 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Cust, N. Slimani, R. Kaaks, M. van Bakel, C. Biessy, P. Ferrari, M. Laville, A. Tjonneland, A. Olsen, K. Overvad, et al. Dietary Carbohydrates, Glycemic Index, Glycemic Load, and Endometrial Cancer Risk within the European Prospective Investigation into Cancer and Nutrition Cohort Am. J. Epidemiol., October 15, 2007; 166(8): 912 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. McCullough, E. V. Bandera, R. Patel, A. V. Patel, T. Gansler, L. H. Kushi, M. J. Thun, and E. E. Calle A Prospective Study of Fruits, Vegetables, and Risk of Endometrial Cancer Am. J. Epidemiol., October 15, 2007; 166(8): 902 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zheng, W.-H. Chow, G. Yang, F. Jin, N. Rothman, A. Blair, H.-L. Li, W. Wen, B.-T. Ji, Q. Li, et al. The Shanghai Women's Health Study: Rationale, Study Design, and Baseline Characteristics Am. J. Epidemiol., December 1, 2005; 162(11): 1123 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Xu, W. Zheng, Y. B. Xiang, Z. X. Ruan, J. R. Cheng, Q. Dai, Y. T. Gao, and X. O. Shu Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study BMJ, May 29, 2004; 328(7451): 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Fowke, F.-L. Chung, F. Jin, D. Qi, Q. Cai, C. Conaway, J.-R. Cheng, X.-O. Shu, Y.-T. Gao, and W. Zheng Urinary Isothiocyanate Levels, Brassica, and Human Breast Cancer Cancer Res., July 15, 2003; 63(14): 3980 - 3986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D Terry, T. E Rohan, and A. Wolk Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence Am. J. Clinical Nutrition, March 1, 2003; 77(3): 532 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Hale, C. L. Hughes, and J. M. Cline Endometrial Cancer: Hormonal Factors, the Perimenopausal ""Window of Risk,"" and Isoflavones J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 3 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Terry, A. Wolk, H. Vainio, and E. Weiderpass Fatty Fish Consumption Lowers the Risk of Endometrial Cancer: A Nationwide Case-Control Study in Sweden Cancer Epidemiol. Biomarkers Prev., January 1, 2002; 11(1): 143 - 145. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. C. Willett Diet and Cancer Oncologist, October 1, 2000; 5(5): 393 - 404. [Abstract] [Full Text]
|
|