American Journal of Epidemiology Vol. 136, No. 5: 538-545
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
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Postprandial Lipemia: Reliability in an Epidemiologic Field Study
1Department of Medicine, Baylor College of Medicine, and The Methodist Hospital Houston, TX
2Department of Biostatistics, University of North Carolina Chapel Hill, NC
3Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute Bethesda, MD
Reprint requests to Dr. Spencer A Brown, The Methodist Hospital, Mail Stop A-601, 6565 Fannin Avenue, Houston, TX 77030
Ten subjects from the Forsyth Country, North Carolina, and Washington Country, Maryland, field centers in the Atherosclerosis Risk in Communities Study had two fat tolerance tests within a 10-day period from September 1988 to February 1989 to determine the reproducibility of markers for postprandial lipemia. No significant differences between visits were found in fasting mean plasma lipids, lipoproteins, and apolipoproteins. Postprandial triglycerides and retinyl palmitate were measured at 3.5 and 9.0 hours after the test meal in whole plasma. There were no significant differences in the mean levels of these analysis between visits. The correlation of triglycerides between repeat visits at 9.0 hours (r= 0.87) was stronger than in fasting samples (r= 0.67) or at 3.5 hours (r= 0.69). The mean plasma retinyl palmitate level at 3.5 hours was 15% higher than at the 9.0-hour level. The correlation of repeat measures of retinyl palmitate at 9.0 hours (r= 0.94) was much stronger than at 3.5 hours (r= 0.79). In conclusion, estimates of reliability in postprandial measurements of 9.0-hour triglycer-ides and retinyl palmitate levels were as strong as fasting lipid measurements of total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, high density lipoprotein3 cholesterol, and both postprandial triglyceride measurements exceeded that of fasting triglyceride (r= 0.67). Am J Epidemiol 1992; 136: 538–45
lipoproteins; HDL cholesterol; lipoproteins; LDL cholesterol; triglycerides
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