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American Journal of Epidemiology Vol. 136, No. 4: 417-421
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Ingested Arsenic, Keratoses, and Bladder Cancer

Jack Cuzick1,, Peter Sasieni1 and Susan Evans2

1Department of Mathematics, Statistics, and Epldemiology, Imperial Cancer Research Fund Lincoln's Inn Fields, London WC2A 3PX, England
2Liverpool Hospital Prescot Street, Liverpool L69 38X, England

Reprint requests to Dr. Jack Cuzick, Department of Mathematics, Statistics, and Epidemiology, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX, England

A cohort of 478 patients treated with Fowler's solution (potassium arsenite) in Lancashire, England, during the penod 1945–1969 and previously followed until January 1, 1980, was followed for an additional 11 years. A significant excess of bladder cancer mortality occurred (observed/expected ratio = 5/1.6; p = 0.05). No excess was found for other causes of death. In a subcohort of 142 patients examined for signs of arsenicism around 1970, all 11 subsequent cancer deaths occurred in those with signs of arsenicism (p = 0.0009).

arsenic; bladder neoplasms; keratosis


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