American Journal of Epidemiology Vol. 136, No. 1: 71-80
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Immunologic Markers of Progression to Acquired Immunodeficiency Syndrome are Time-Dependent and Illness-Specific
1Institute of Medical Biometry, University of Tubingen Tubingen, Germany
2Viral Epidemiology Section, National Cancer Institute Rockville, MD
3Abbott Diagnostics Products GmbH, W-6200 Wiesbaden-Delkenheim Germany
4Department of Pathology, Uniformed Services of the Health Sciences Bethesda, MD
5Institute of Medical Chemistry and Biochemistry, Innsbruck University Innsbruck, Austria
Reprint requests to Dr. James J. Goedert, Viral Epidemiology Section, National Cancer Institute, National Institutes of Health, Building EPN, Room 434, 6130 Executive Blvd., Rockville, MD 20852.
Since prevalent cohorts may be biased by the duration of human immunodeficiency virus (HIV) infection (onset bias), it is useful to assess the potential predictive value of markers in incident cohorts of HIV-positive subjects for whom the date of seroconversion is known or can reliably be estimated. Of 131 homosexual men with HIV-1 seroconversion from New York City and Washington, DC, who were evaluated annually beginning in 1982, 60 developed acquired immunodeficiency syndrome (AIDS) by the end of 1989. The prognostic significance of immunologic markers (proportion of CD4+ T-lymphocytes, neopterin, ß2-microglobulin, serum interferon, and anti-p24 antibody) and of a virologic marker (HIV p24 antigen) was determined using measurements made at defined time intervals after the known or estimated date of HIV seroconversion. When measurements made 3 years after seroconversion were used, all markers except anti-p24 antibody were found to be significant estimators of AIDS risk in univariate analyses. In multivariate Cox regression modeling, the maximum information was obtained by including neopterin, interferon, and the CD4+ T-lymphocyte proportion. The predictive value of markers after HIV seroconversion could change considerably from one interval to another. Elevated levels of ß2-microglobulin and neopterin significantly predicted the development of Kaposi‘s sarcoma. These two markers were highly correlated (r=0. 74). The authors conclude that immunologic markers can be important for an HIV staging system for estimating prognosis and facilitating early therapeutic intervention in HIV-positive patients.
beta 2-microglobulin; HIV antibodies; HIV antigens; HIV-1; interferons; proportional hazards models; pteridines; T4 lymphocytes
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. J. Stratigos, D. Malanos, G. Touloumi, A. Antoniou, I. Potouridou, D. Polydorou, A. D. Katsambas, D. Whitby, N. Mueller, J. D. Stratigos, et al. Association of Clinical Progression in Classic Kaposi's Sarcoma With Reduction of Peripheral B Lymphocytes and Partial Increase in Serum Immune Activation Markers Arch Dermatol, November 1, 2005; 141(11): 1421 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Gallafent, S. E. Buskin, P. B. De Turk, and D. M. Aboulafia Profile of Patients With Kaposi's Sarcoma in the Era of Highly Active Antiretroviral Therapy J. Clin. Oncol., February 20, 2005; 23(6): 1253 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Sloand, J. Maciejewski, P. Kumar, S. Kim, A. Chaudhuri, and N. Young Protease inhibitors stimulate hematopoiesis and decrease apoptosis and ICE expression in CD34+ cells Blood, October 15, 2000; 96(8): 2735 - 2739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Fahey Cytokines, Plasma Immune Activation Markers, and Clinically Relevant Surrogate Markers in Human Immunodeficiency Virus Infection Clin. Vaccine Immunol., September 1, 1998; 5(5): 597 - 603. [Full Text]
|
|
|
|
 |
|
 N. Sacktor, X. Liu, M. Popescu, K. Marder, Y. Stern, and R. Mayeux Serum Neopterin Level Predicts HIV-Related Mortality but Not Progression to AIDS or Development of Neurological Disease in Gay Men and Parenteral Drug Users Arch Neurol, July 1, 1995; 52(7): 676 - 679. [Abstract] [PDF]
|
|
|
|
 |
|
 A N Phillips, C A Sabin, J Elford, M Bofill, G Janossy, and C A Lee Use of CD4 lymphocyte count to predict long term survival free of AIDS after HIV infection BMJ, July 30, 1994; 309(6950): 309 - 313. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Rabeneck and N. P. Wray Predicting the Outcomes of Human Immunodeficiency Virus Infection: How Well Are We Doing? Arch Intern Med, December 27, 1993; 153(24): 2749 - 2755. [Abstract] [PDF]
|
|
|
|
 |
|
 M L Mirsky, Y Da, and H A Lewin Detection of bovine leukemia virus proviral DNA in individual cells. Genome Res., May 1, 1993; 2(4): 333 - 340. [Abstract] [PDF]
|
|