American Journal of Epidemiology Vol. 135, No. 7: 783-791
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
The Influence of Aging on Plasma Sex Hormones in Men: The Telecom Study
1INSERM U.21 villejuif France
2Service d'Endocrinotogie et Département de Santé Publique.H
pital Henn Mondor Créteil France
3Department of Community and Family Medicine M-007 University of California San Diego La Jolla CA
4Fondation de Recherche en Horrnonotogie Paris France
5Laboratoires de la Direction de I'Acton Sociale de I'Enfance et de la Sante (DASES) Paris France
Reprint requests to Dr. Dominique Simon, INSERM U.21, 16 avenue Paul VaiDant Couturier, 94807 Villejuif, Cedex, France.
From April 1985 to July 1987, 1,408 healthy white men aged 20–60 years in Paris, France, recruited on an occupational basis, underwent a physical examination and measurements of plasma sex hormones in a cross-sectional study. Both total testosterone and estradbl showed a significant stepwise decrease with age (p < 0.001) starting in the earty adult years, while estrone did not vary. These relations of testosterone and estradbl with age remained significant after adjustment for body mass index, subscapular skinfold, and tobacco and alcohol consumptions, and they were not modified by exclusbn of the men who reported chronic disease. Both the mechanism for the early decrease in testosterone and its clinical significance merit further investigation. Am J Epidemiol 1992;135:783–91.
aging; estradiol; estrone; men; sex hormones; testosterone
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