Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (81)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Thomas, D. B.
Right arrow Articles by West, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thomas, D. B.
Right arrow Articles by West, D. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 135, No. 7: 734-748
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Breast Cancer In Men: Risk Factors with Hormonal Implications

David B. Thomas1,1, L. Margarita Jimenez2,1, Anne McTieman1,3, Karin Rosenblatt1, Helge Stalsberg4, Annette Stemhagen5, W. Douglas Thompson6, Mary G. McCrea Curnen7, William Satariano8, Donald F. Austin9, Raymond S. Greenberg10, Charles Key11, Laurence N. Kolonel12 and Dee W. West13

1Program in Epidemiology Fred Hutchinson Cancer Research Center Seattle WA
2lnstituto Regional de Investigacton en Salud Publica Universidad de Guadalajara Guadalajara Jalisco Mexico
3University of Washington School of Medicine Seattle WA
4University of Tromsø Tromsø Norway
5Pharmaceutical Division CIBA-GEIGY Corp Summit NJ
6University of Southern Maine Portland ME
7Connecticut Cancer Epidemiology Unit New Haven CT
8School of Public Health University of California Berke-ley CA
9Resource for Cancer Epidemiology Department of Health Services Emeryville CA
10School of Public Health Emory University Atlanta GA
11New Mexico Tumor Registry Albuquerque NM
12Epidemiology Program Cancer Research Center of Hawai Honolulu HI
13Northern California Cancer Center Alameda CA

Reprint requests to to Dr David B Thomas, Program in Epidemiology, MP-474, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA 98104.

Cases included in a population-based case-control study of breast cancer in men were recruited from 10 geographic areas of the United States from 1983 to 1986. Controls, matched to cases on age and geographic area, were selected by random digit dialing for men under age 65 years and from Health Care Financing Administration files for older men. Results are based on responses from 227 cases and 300 controls to questions asked in a standardized personal interview. An increased risk of breast cancer was most strongly associated with undescended testes and was also related to orchiectomy, orchitis, testjcular injury, late puberty, and infertility; and a decreasing trend in risk was observed with an increasing number of children. Relative risk estimates were also elevated in relation to a history of high blood cholesterol, rapid weight gain, benign breast conditions, and possibly obesity. These findings suggest that breast cancer in men develops in response to androgen deficiency associated with testicular dysfunction and under conditions associated with excess estrogen. Risk was also found to be elevated in men with a history of amphetamine use, diabetes, and cigar smoking and reduced in men with prior head trauma. Am J Epidemiol 1992;135:734–48.

breast neoplasms; cryptorchism; testicular diseases


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 jvdiHome page
G. D. Cassali, A. C. Bertagnolli, E. Ferreira, and M. C.C. Malta
A simple ductal mammary papilloma in a male maned wolf (Chrysocyon brachyurus)
J Vet Diagn Invest, January 1, 2009; 21(1): 153 - 155.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. A. Brinton, D. A. Richesson, G. L. Gierach, J. V. Lacey Jr, Y. Park, A. R. Hollenbeck, and A. Schatzkin
Prospective Evaluation of Risk Factors for Male Breast Cancer
J Natl Cancer Inst, October 15, 2008; 100(20): 1477 - 1481.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
S. H. Giordano
A Review of the Diagnosis and Management of Male Breast Cancer
Oncologist, August 1, 2005; 10(7): 471 - 479.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. R. Weiss, K. B. Moysich, and H. Swede
Epidemiology of Male Breast Cancer
Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 20 - 26.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Kwiatkowska, M. Teresiak, V. Filas, A. Karczewska, D. Breborowicz, and A. Mackiewicz
BRCA2 Mutations and Androgen Receptor Expression as Independent Predictors of Outcome of Male Breast Cancer Patients
Clin. Cancer Res., October 1, 2003; 9(12): 4452 - 4459.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
S. H. Giordano, A. U. Buzdar, and G. N. Hortobagyi
Breast Cancer in Men
Ann Intern Med, October 15, 2002; 137(8): 678 - 687.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. Auvinen, R. E. Curtis, and E. Ron
Risk of Subsequent Cancer Following Breast Cancer in Men
J Natl Cancer Inst, September 4, 2002; 94(17): 1330 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
J. D Fackenthal, D. J Marsh, A.-L. Richardson, S. A Cummings, C. Eng, B. G Robinson, and O. I Olopade
Male breast cancer in Cowden syndrome patients with germline PTEN mutations
J. Med. Genet., March 1, 2001; 38(3): 159 - 164.
[Abstract] [Full Text]

Home page
 J. Epidemiol. Community HealthHome page
R. A Wiseman
Breast cancer hypothesis: a single cause for the majority of cases
J Epidemiol Community Health, November 1, 2000; 54(11): 851 - 858.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.