American Journal of Epidemiology Vol. 135, No. 4: 341-346
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Cigarette Smoking and the Incidence of Cervical Intraepithelial Neoplasia, Grade III, and Cancer of the Cervix Uteri
1Institute of Community Medicine, University of Tromsö Tromsö, Norway.
2University of Alabama at Birmingham, Birmingham, AL. Present address: Emory University School of Public Health Atlanta, GA.
3Institute of Medical Biology, University of Tromsö Tromsö, Norway.
Reprint requests to Dr. Inger T. Gram, Institute of Community Medicine, University of Tromsö, Postuttak N-9000, Tromsö, Norway.
The relation between cigarette smoking and cervical intraepithelial neoplasia, grade III (CIN III), and cervical cancer was examined among a cohort of 6,812 women in Tromsö, Norway, between 1980 and 1989. During the 52,844 person-years of observation, 185 incident cases (177 women with CIN III and eight with cervical cancer) were recorded in the regional pathology registry. The age-adjusted incidence rates of CIN III and cervical cancer were 267/100,000 person-years among women who had never smoked, 183/100,000 person-years among exsmokers, and 476/100,000 person-years among current smokers. A multivariate model containing terms for age, marital status, and frequency of intoxication yielded a relative rate for current smokers compared with nonsmokers of 1.5 (95% confidence interval 1.0–2.2). Statistical trend tests for the number of cigarettes smoked per day (never, 1–14, and 
15 cigarettes), years of smoking (never, 1–9, and 10 years), and age started smoking (<16, 16–18, 19–21, and 22 years) all yielded significant results. These findings support the opinion that CIN III and cervical cancer are a smoking-related disease. Am J Epidemiol 1992;135:341–6.
cervix dysplasia; cervix neoplasms; follow-up studies; smoking
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  International Collaboration of Epidemiological Stu Cervical Carcinoma and Sexual Behavior: Collaborative Reanalysis of Individual Data on 15,461 Women with Cervical Carcinoma and 29,164 Women without Cervical Carcinoma from 21 Epidemiological Studies Cancer Epidemiol. Biomarkers Prev., April 1, 2009; 18(4): 1060 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Trimble, S. Piantadosi, P. Gravitt, B. Ronnett, E. Pizer, A. Elko, B. Wilgus, W. Yutzy, R. Daniel, K. Shah, et al. Spontaneous Regression of High-Grade Cervical Dysplasia: Effects of Human Papillomavirus Type and HLA Phenotype Clin. Cancer Res., July 1, 2005; 11(13): 4717 - 4723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Lynch, M. J. Casey, T. G. Shaw, and J. F. Lynch Hereditary Factors in Gynecologic Cancer Oncologist, October 1, 1998; 3(5): 319 - 338. [Abstract] [Full Text]
|
|