American Journal of Epidemiology Vol. 135, No. 3: 266-273
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Is Abdominal Body Fat Distribution a Major Explanation for the Sex Difference in the Incidence of Myocardial Infarction?
The Study of Men Born in 1913 and The Study of Women, Göteborg, Sweden
1Department of Medicine I, Sahigrenska Hospital Gothenburg, Sweden
2Department of Primary Health Care, Gothenburg University Sweden
3Department of Medicine D, Sahigrenska Hospital Gothenburg, Sweden
4Department of Family Medicine, Uppsala University Uppsala, Sweden
5The Nordic School of Pubfic Health Gothenburg, Sweden
6Department of Medicine, Östra Hosprtal Gothenburg, Sweden
Reprint requests to Dr Bo Larsson, Department of Mecficine I, Sahigrenska Hospital, S-413 45 Goteborg, Sweden
The authors considered whether the difference in body fat distribution between men and women, measured as waist: hip ratio, might explain part of the sex difference in coronary heart disease incidence in prospective population studies of 1,462 women and 792 men. In these studies, conducted in Sweden, men were found to have about four times higher odds for coronary heart disease than women during a 12-year follow-up period (men, 1967 to 1979; women, 1968–1969 to 1980–1981). Controlling for differences in blood pressure, serum cholesterol, smoking, and body mass index only marginally altered the magnitude of the mate-female difference. When waisthip ratio, which predicted coronary heart disease rates in both sexes, was also considered, the sex difference in coronary heart disease risk was significantly reduced and virtually disappeared (odds ratios = 1.0–1.1; nonsignificant). The findings suggest that body fat distribution or a factor highly correlated with waistihip ratio (genetic, hormonal, or behavioral) may help to explain the sex differences in coronary heart disease. Am J Epidemiol 1992;135:266–73.
coronary disease; men; myocardial infarction; obesity; sex characteristics; women
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. J. Campbell Why do men and women differ in their risk of myocardial infarction? Eur. Heart J., April 1, 2008; 29(7): 835 - 836. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bhasin, R. A. Parker, F. Sattler, R. Haubrich, B. Alston, T. Umbleja, C. M. Shikuma, and for the AIDS Clinical Trials Group Protocol A5079 Effects of Testosterone Supplementation on Whole Body and Regional Fat Mass and Distribution in Human Immunodeficiency Virus-Infected Men with Abdominal Obesity J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 1049 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Vega, B. Adams-Huet, R. Peshock, D. Willett, B. Shah, and S. M. Grundy Influence of Body Fat Content and Distribution on Variation in Metabolic Risk J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4459 - 4466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Lawlor, G. Davey Smith, S. Ebrahim, C. Thompson, and N. Sattar Plasma Adiponectin Levels Are Associated with Insulin Resistance, But Do Not Predict Future Risk of Coronary Heart Disease in Women J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5677 - 5683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Nicklas, B. W. J. H. Penninx, M. Cesari, S. B. Kritchevsky, A. B. Newman, A. M. Kanaya, M. Pahor, D. Jingzhong, and T. B. Harris Association of Visceral Adipose Tissue with Incident Myocardial Infarction in Older Men and Women: The Health, Aging and Body Composition Study Am. J. Epidemiol., October 15, 2004; 160(8): 741 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A Lawlor, S. Ebrahim, P. Whincup, J. Sterne, O. Papacosta, G. Wannamethee, S. Dhanjil, M. Griffin, A. N Nicolaides, and G. Davey Smith Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British regional heart study J Epidemiol Community Health, August 1, 2004; 58(8): 700 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Linder, P. Arner, A. Flores-Morales, P. Tollet-Egnell, and G. Norstedt Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women J. Lipid Res., January 1, 2004; 45(1): 148 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Carr The Emergence of the Metabolic Syndrome with Menopause J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2404 - 2411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E Roeters van Lennep, H.T. Westerveld, D.W. Erkelens, and E. E van der Wall Risk factors for coronary heart disease: implications of gender Cardiovasc Res, February 15, 2002; 53(3): 538 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Barnekow-Bergkvist, G. Hedberg, U. Janlert, and E. Jansson Adolescent determinants of cardiovascular risk factors in adult men and women Scand J Public Health, July 1, 2001; 29(3): 208 - 217. [Abstract] [PDF]
|
|
|
|
|
|
W.D Ashton, K Nanchahal, and D.A Wood Body mass index and metabolic risk factors for coronary heart disease in women Eur. Heart J., January 1, 2001; 22(1): 46 - 55. [Abstract] [PDF]
|
|
|
|
 |
|
 B. L. Wajchenberg Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome Endocr. Rev., December 1, 2000; 21(6): 697 - 738. [Abstract] [Full Text]
|
|
|
|
|
|
S. L. Crawford and C. B. Johannes The Epidemiology of Cardiovascular Disease in Postmenopausal Women J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1803 - 1806. [Full Text]
|
|
|
|
 |
|
 P. Jousilahti, E. Vartiainen, J. Tuomilehto, and P. Puska Sex, Age, Cardiovascular Risk Factors, and Coronary Heart Disease : A Prospective Follow-Up Study of 14 786 Middle-Aged Men and Women in Finland Circulation, March 9, 1999; 99(9): 1165 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lonnqvist, A. Thorne, V. Large, and P. Arner Sex Differences in Visceral Fat Lipolysis and Metabolic Complications of Obesity Arterioscler Thromb Vasc Biol, July 1, 1997; 17(7): 1472 - 1480. [Abstract] [Full Text]
|
|
|
|
|
|
P. J. Nestel, S. E. Pomeroy, T. Sasahara, T. Yamashita, Y. L. Liang, A. M. Dart, G. L. Jennings, M. Abbey, and J. D. Cameron Arterial Compliance in Obese Subjects Is Improved With Dietary Plant n-3 Fatty Acid From Flaxseed Oil Despite Increased LDL Oxidizability Arterioscler Thromb Vasc Biol, June 1, 1997; 17(6): 1163 - 1170. [Abstract] [Full Text]
|
|
|
|
|
|
E. Barrett-Connor Sex Differences in Coronary Heart Disease: Why Are Women So Superior? The 1995 Ancel Keys Lecture Circulation, January 7, 1997; 95(1): 252 - 264. [Full Text]
|
|
|
|
 |
|
 D. Rastenyte, J. Tuomilehto, S. Domarkiene, Z. Cepaitis, and R. Reklaitiene Risk Factors for Death From Stroke in Middle-aged Lithuanian Men : Results From a 20-Year Prospective Study Stroke, April 1, 1996; 27(4): 672 - 676. [Abstract] [Full Text]
|
|
|
|
|
|
M. C. Mahaney, J. Blangero, A. G. Comuzzie, J. L. VandeBerg, M. P. Stern, and J. W. MacCluer Plasma HDL Cholesterol, Triglycerides, and Adiposity : A Quantitative Genetic Test of the Conjoint Trait Hypothesis in the San Antonio Family Heart Study Circulation, December 1, 1995; 92(11): 3240 - 3248. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. M. Kaplan The Treatment of Hypertension in Women Arch Intern Med, March 27, 1995; 155(6): 563 - 567. [Abstract] [PDF]
|
|
|
|
 |
|
 D. E. Smith, C. E. Lewis, J. L. Caveny, L. L. Perkins, G. L. Burke, and D. E. Bild Longitudinal Changes in Adiposity Associated With Pregnancy: The CARDIA Study JAMA, June 8, 1994; 271(22): 1747 - 1751. [Abstract] [PDF]
|
|