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American Journal of Epidemiology Vol. 135, No. 3: 259-265
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Serum Cholesterol Concentration and Primary Malignant Brain Tumors: A Prospective Study

George Davey Smith1, James D. Neaton2, Yoav Ben-Shlomo3, Martin Shipley1 and Deborah Wentworth2

1Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine Keppel Street, London WC1E 7HT, United Kingdom
2Multiple Risk Factor Intervention Trial Coordinating Center, Coordinating Centers for Btometric Research, Division of BiostatistJcs, School of Public Health, University of Minnesota Minneapolis, MN
3Department of Epidemiology and Public Health, University College and Middlesex School of Medicine 66–72 Gower Street, London WC1E 6EA, United Kingdom

Reprint requests to Dr. George Davey Smith, Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom

Case-control studies and a prospective study have suggested a positive relation between serum cholesterol and brain tumors. To examine this association further, mortality from malignant brain tumors among men who participated in the Multiple Risk Factor Intervention Trial (a prospective study, 1973–1986) who indicated they were not black were examined. No relation was seen between age-standardized mortality rates and baseline serum cholesterol. Excluding deaths occurring during the first 5 years or adjusting for median census tract income did not alter this finding. This suggests that no generalizabte relation between serum cholesterol and primary malignant brain tumors exists. An environmental factor associated with serum cholesterol in some, but not all populations, may explain the apparently contradictory results. Am J Epidemiol 1992;135:259–65.

brain neoplasms; cholesterol; prospective studies


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