American Journal of Epidemiology Vol. 135, No. 2: 115-121
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Serum Retinol, Beta-Carotene, Vitamin E, and Selenium As Related to Subsequent Cancer of Specific Sites
1Department of Epidemiology, School of Hygiene and Public Health The Johns Hopkins University, Baltimore, MD.
2Oncology Center, The Johns Hopkins Hospital Baltimore, MD.
Reprint requests to Dr. George W. Comstock, Training Center for Public Health Research, Box 2067, Hagerstown, MD 21742–2067.
Case–control differences in prediagnostic serum levels of retinol, beta–carotene, vitamin E, and selenium are compared for 10 cancer sites in 10 study populations. For all four nutrients, the majority of results showed lower levels among persons who subsequently became cases than among controls. Low levels of beta–carotene were most likely to be associated with subsequent cancer, but there were marked differences by cancer site. The results indicate that it is unlikely that any of these serum micronutrients are associated with protection against carcinogenesis at all sites. A plea is made for greater emphasis on replication of results, for reporting findings for all sites no matter how small the number of cases may be, and for keeping constantly in mind the fact that observational associations are not necessarily causal in nature. Am J Epidemiol 1992;135:115–21.
carotene; neoplasms; selenium; vitamin A; vitamin E
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Honors and Awards * Bibliography of Peer-Reviewed Journal Articles Am. J. Epidemiol., October 1, 2008; 168(7): 845 - 854. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bardia, I. M. Tleyjeh, J. R. Cerhan, A. K. Sood, P. J. Limburg, P. J. Erwin, and V. M. Montori Efficacy of Antioxidant Supplementation in Reducing Primary Cancer Incidence and Mortality: Systematic Review and Meta-analysis Mayo Clin. Proc., January 1, 2008; 83(1): 23 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C Larsson, L. Bergkvist, I. Naslund, J. Rutegard, and A. Wolk Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study Am. J. Clinical Nutrition, February 1, 2007; 85(2): 497 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. T. Akbaraly, J. Arnaud, I. Hininger-Favier, V. Gourlet, A.-M. Roussel, and C. Berr Selenium and Mortality in the Elderly: Results from the EVA Study Clin. Chem., November 1, 2005; 51(11): 2117 - 2123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nouraie, P. Pietinen, F. Kamangar, S. M. Dawsey, C. C. Abnet, D. Albanes, J. Virtamo, and P. R. Taylor Fruits, Vegetables, and Antioxidants and Risk of Gastric Cancer among Male Smokers Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2087 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-H. Lee, M. D. Gross, and D. R. Jacobs Jr Association of Serum Carotenoids and Tocopherols with {gamma}-Glutamyltransferase: The Cardiovascular Risk Development in Young Adults (CARDIA) Study Clin. Chem., March 1, 2004; 50(3): 582 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Rudolph, T. L. Vaughan, A. R. Kristal, P. L. Blount, D. S. Levine, P. C. Galipeau, L. J. Prevo, C. A. Sanchez, P. S. Rabinovitch, and B. J. Reid Serum Selenium Levels in Relation to Markers of Neoplastic Progression Among Persons With Barrett's Esophagus J Natl Cancer Inst, May 21, 2003; 95(10): 750 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gross, X. Yu, P. Hannan, C. Prouty, and D. R Jacobs Jr Lipid standardization of serum fat-soluble antioxidant concentrations: the YALTA study Am. J. Clinical Nutrition, February 1, 2003; 77(2): 458 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Duffield-Lillico, M. E. Reid, B. W. Turnbull, G. F. Combs Jr., E. H. Slate, L. A. Fischbach, J. R. Marshall, and L. C. Clark Baseline Characteristics and the Effect of Selenium Supplementation on Cancer Incidence in a Randomized Clinical Trial: A Summary Report of the Nutritional Prevention of Cancer Trial Cancer Epidemiol. Biomarkers Prev., July 1, 2002; 11(7): 630 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ching, D. Ingram, R. Hahnel, J. Beilby, and E. Rossi Serum Levels of Micronutrients, Antioxidants and Total Antioxidant Status Predict Risk of Breast Cancer in a Case Control Study J. Nutr., February 1, 2002; 132(2): 303 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Prakash, R. M. Russell, and N. I. Krinsky In Vitro Inhibition of Proliferation of Estrogen-Dependent and Estrogen-Independent Human Breast Cancer Cells Treated with Carotenoids or Retinoids J. Nutr., May 1, 2001; 131(5): 1574 - 1580. [Abstract] [Full Text]
|
|
|
|
|
|
P. Wallstrom, E. Wirfalt, P. H Lahmann, B. Gullberg, L. Janzon, and G. Berglund Serum concentrations of {beta}-carotene and {{alpha}}-tocopherol are associated with diet, smoking, and general and central adiposity Am. J. Clinical Nutrition, April 1, 2001; 73(4): 777 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Helzlsouer, H.-Y. Huang, A. J. Alberg, S. Hoffman, A. Burke, E. P. Norkus, J. S. Morris, and G. W. Comstock Association Between {{alpha}}-Tocopherol, {{gamma}}-Tocopherol, Selenium, and Subsequent Prostate Cancer J Natl Cancer Inst, December 20, 2000; 92(24): 2018 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Malila, J. Virtamo, M. Virtanen, D. Albanes, J. A. Tangrea, and J. K. Huttunen The Effect of {{alpha}}-Tocopherol and {beta}-Carotene Supplementation on Colorectal Adenomas in Middle-Aged Male Smokers Cancer Epidemiol. Biomarkers Prev., June 1, 1999; 8(6): 489 - 493. [Abstract] [Full Text]
|
|
|
|
|
|
L. N. Kolonel, A. M. Y. Nomura, and R. V. Cooney Dietary Fat and Prostate Cancer: Current Status J Natl Cancer Inst, March 3, 1999; 91(5): 414 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wu, K. J. Helzlsouer, G. W. Comstock, S. C. Hoffman, M. R. Nadeau, and J. Selhub A Prospective Study on Folate, B12, and Pyridoxal 5'-Phosphate (B6) and Breast Cancer Cancer Epidemiol. Biomarkers Prev., March 1, 1999; 8(3): 209 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ip Lessons from Basic Research in Selenium and Cancer Prevention J. Nutr., November 1, 1998; 128(11): 1845 - 1854. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. C. Clark, G. F. Combs Jr, B. W. Turnbull, E. H. Slate, D. K. Chalker, J. Chow, L. S. Davis, R. A. Glover, G. F. Graham, E. G. Gross, et al. Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial JAMA, December 25, 1996; 276(24): 1957 - 1963. [Abstract] [PDF]
|
|
|
|
 |
|
 Beta Carotene Cancer Prevention Study Group The Al The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers N. Engl. J. Med., April 14, 1994; 330(15): 1029 - 1035. [Abstract] [Full Text]
|
|