American Journal of Epidemiology Vol. 135, No. 10: 1093-1102
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
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Human Papillomaviruses, Herpes Simplex Viruses, and the Risk of Oral Cancer in Men
1Division of Public Health Sciences, Fred Hutchmson Cancer Research Center Seattle, WA
2Department of Epidemiology, University of Washington Seattle, WA
3Department of Pathology, University of Washington Seattle, WA
4Department of Biostatistics, University of Washington Seattle, WA
5Department of Laboratory Medicine, University of Washington Seattle, WA
Reprint requests to Dr Christopher Maden, Seattle-King County Department of Public Health, Epidemiology Unit, HIV/AIDS Section, 3rd Floor Yesler Building, 400 Yesler Way, Seattle, WA 98104
A population-based case-control study was conducted in western Washington state to examine the relations between infection with human papilloma viruses (HPV), herpes simplex viruses (HSV), and risk of oral squamous cell cancer in men. Interviews were completed on 131 oral cancer cases diagnosed between January 1985 and December 1989 and 136 controls frequency matched to cases on age and date of diagnosis who were obtained by random digit dialing. The risk for oral cancer among men with 30 or more sexual partners was 2.4 times that of men with four or fewer partners (95% confidence.interval (Cl) 1.0–5.9). Men who ever practiced oral sex had lower risk for oral cancer relative to men who never practiced oral sex (relative risk (RR) = 0.4, 95% Cl 0.2–0.8). Analyses of exfoliated oral cavity cells for the presence of HPV-6 DNA with polymerase chain reaction revealed that men with an oral HPV-6 infection had 2.9 times the risk for oral cancer of noninfected men (95% Cl 1.1–7.3), whereas men with an oral HPV-16 infection had 6.2 times the risk for oral cancer of noninfected men (crude RR = 6.2, 95% Cl 0.7–52.2). Relative risks associated with serologically detected HSV-1 and HSV-2 infections were 0.8 (95% Cl 0.3–1.7) and 1.8 (95% Cl 0.7–4.6), respectively. The authors conclude that HPV-6 is associated with oral cancer. Although men infected with HPV-16 and HSV-2 were at elevated risk, these associations may have been due to chance. The role of specific sexual practices in the transmission of viruses to the oral cavity remains unclear. Am J Epidemiol 1992; 135: 1093–1102
herpes simplex; homosexuality; oral neoplasms; papillomaviruses; sex behavior; sexually transmitted diseases
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