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American Journal of Epidemiology Vol. 134, No. 8: 818-824
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Polycystic Ovaries and the Risk of Breast Cancer

Marilie D. Gammon1 and W. Douglas Thompson2

1Division of Epidemiology, Columbia University School of Public Health New York, NY
2Department of Applied Medical Sciences, University of Southern Maine Portland, ME

Data from a case-control study that was conducted between 1980 and 1982 were analyzed to investigate the possible association between polycystic ovaries and the risk of breast cancer. The multicenter, population-based study included in-home interviews with 4,730 women with breast cancer and 4, 688 control women aged 20–54 years. The age-adjusted odds ratio for breast cancer among women with a self-reported history of physician-diagnosed polycystic ovaries was 0.52 (95% confidence interval 0.32–0.87). The inverse association was not an artifact of infertility, age at first birth, or surgical menopause. Because women with this syndrome have abnormal levels of certain endogenous hormones, the observation of a low risk of breast cancer in this group may provide new insights into hormonal influences on breast cancer.

breast neoplasms; polycystic ovary syndrome


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