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American Journal of Epidemiology Vol. 134, No. 3: 250-256
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Carotid Atherosclerosis Measured by B-Mode Ultrasound in Populations: Associations with Cardiovascular Risk Factors in the ARIC Study
1Department of Epidemiology, University of North Carolina School of Public Health Chapel Hill, NC.
2Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute Bethesda, MD.
3ARIC Ultrasound Reading Center Winston-Salem, NC.
4Department of Biostatstics, University of North Carolina School of Public Health Chapel Hill, NC.
5Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health Baltimore, MD.
Reprint requests to Dr. Gerardo Heiss, Department of Epidemiology, CB#7400, McGavran-Greenberg Hall, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7400
To assess whether carotid atherosclerosis measured by B-mode ultrasound is related to cardiovascular risk factors, 386 cases with carotid artery wall thickening and an equal number of controls free of arterial intima-media thickening were drawn from the cohort of the Atherosclerosis Risk in Communities (ARIC) Study examined in four communities in the United States between 1988 and 1990. Cases and controls were individually matched on sex, race, age group, study center, and date of examination. The mean values of total cholesterol, low density lipoprotein (LDL) cholesterol, total triglyceride, blood pressure, and pack-years of cigarette smoking were higher in cases than controls. Mean high density lipoprotein (HDL) cholesterol was lower in cases than controls. Case-control differences were all statistically significant. Multivariable-adjusted odds ratios point to differences of considerable magnitude in the risk of carotid atherosclerosis between groups defined by clinical and public health-oriented risk factor cut-points. Am J Epidemiol 1991;134:2506.
arteriosclerosis; cardiovascular diseases; hypertension; lipoproteins; smoking; ultrasonics
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R. L. Sacco, R. T. Benson, D. E. Kargman, B. Boden-Albala, C. Tuck, I-F. Lin, J. F. Cheng, M. C. Paik, S. Shea, and L. Berglund High-Density Lipoprotein Cholesterol and Ischemic Stroke in the Elderly: The Northern Manhattan Stroke Study JAMA, June 6, 2001; 285(21): 2729 - 2735. [Abstract] [Full Text] [PDF] |
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J Forsblad, A Gottsater, T Matzsch, and F Lindgarde Predictors of carotid endarterectomy in middle-aged individuals Vascular Medicine, May 1, 2001; 6(2): 81 - 85. [Abstract] [PDF] |
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L. B. Goldstein, R. Adams, K. Becker, C. D. Furberg, P. B. Gorelick, G. Hademenos, M. Hill, G. Howard, V. J. Howard, B. Jacobs, et al. Primary Prevention of Ischemic Stroke : A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association Circulation, January 2, 2001; 103(1): 163 - 182. [Full Text] [PDF] |
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H. Tanaka, F. A. Dinenno, K. D. Monahan, C. A. DeSouza, and D. R. Seals Carotid Artery Wall Hypertrophy With Age Is Related to Local Systolic Blood Pressure in Healthy Men Arterioscler Thromb Vasc Biol, January 1, 2001; 21(1): 82 - 87. [Abstract] [Full Text] [PDF] |
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L. B. Goldstein, R. Adams, K. Becker, C. D. Furberg, P. B. Gorelick, G. Hademenos, M. Hill, G. Howard, V. J. Howard, B. Jacobs, et al. Primary Prevention of Ischemic Stroke : A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association Stroke, January 1, 2001; 32(1): 280 - 299. [Full Text] [PDF] |
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G. Gaeta, M. De Michele, S. Cuomo, P. Guarini, M. C. Foglia, M. G. Bond, and M. Trevisan Arterial Abnormalities in the Offspring of Patients with Premature Myocardial Infarction N. Engl. J. Med., September 21, 2000; 343(12): 840 - 846. [Abstract] [Full Text] [PDF] |
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B. Guillon, C. Tzourio, V. Biousse, V. Adrai, M. G. Bousser, and P. J. Touboul Arterial wall properties in carotid artery dissection: An ultrasound study Neurology, September 12, 2000; 55(5): 663 - 666. [Abstract] [Full Text] [PDF] |
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S. Takiuchi, H. Rakugi, K. Honda, T. Masuyama, N. Hirata, H. Ito, K. Sugimoto, Y. Yanagitani, K. Moriguchi, A. Okamura, et al. Quantitative Ultrasonic Tissue Characterization Can Identify High-Risk Atherosclerotic Alteration in Human Carotid Arteries Circulation, August 15, 2000; 102(7): 766 - 770. [Abstract] [Full Text] [PDF] |
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P. M Ueland, H. Refsum, S. A. Beresford, and S. E. Vollset The controversy over homocysteine and cardiovascular risk Am. J. Clinical Nutrition, August 1, 2000; 72(2): 324 - 332. [Abstract] [Full Text] [PDF] |
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M. Zureik, P. Ducimetiere, P.-J. Touboul, D. Courbon, C. Bonithon-Kopp, C. Berr, and C. Magne Common Carotid Intima-Media Thickness Predicts Occurrence of Carotid Atherosclerotic Plaques : Longitudinal Results From the Aging Vascular Study (EVA) Study Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1622 - 1629. [Abstract] [Full Text] [PDF] |
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R. Klein, A. R. Sharrett, B. E. K. Klein, L. E. Chambless, L. S. Cooper, L. D. Hubbard, and G. Evans Are Retinal Arteriolar Abnormalities Related to Atherosclerosis? : The Atherosclerosis Risk in Communities Study Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1644 - 1650. [Abstract] [Full Text] [PDF] |
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S Manzi, L H Kuller, D Edmundowicz, and K Sutton-Tyrrell Vascular imaging: changing the face of cardiovascular research Lupus, March 1, 2000; 9(3): 176 - 182. [Abstract] [PDF] |
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E. Stensland-Bugge, K. H. Bonaa, O. Joakimsen, and I. Njolstad Sex Differences in the Relationship of Risk Factors to Subclinical Carotid Atherosclerosis Measured 15 Years Later : The Tromso Study Stroke, March 1, 2000; 31(3): 574 - 581. [Abstract] [Full Text] [PDF] |
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C. J. Wiedermann, S. Kiechl, S. Dunzendorfer, P. Schratzberger, G. Egger, F. Oberhollenzer, and J. Willeit Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: Prospective results from the bruneck study J. Am. Coll. Cardiol., December 1, 1999; 34(7): 1975 - 1981. [Abstract] [Full Text] [PDF] |
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F. Bilora, C. Dei Rossi, B. Girolami, A. Casonato, E. Zanon, A. Bertomoro, and A. Girolami Do Hemophilia A and von Willebrand Disease Protect Against Carotid Atherosclerosis? A Comparative Study Between . Coagulopathics and Normal Subjects by Means of Carotid Echo-Color Doppler Scan Clinical and Applied Thrombosis/Hemostasis, October 1, 1999; 5(4): 232 - 235. [Abstract] [PDF] |
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C. Skoglund-Andersson, R. Tang, M. G. Bond, U. de Faire, A. Hamsten, and F. Karpe LDL Particle Size Distribution Is Associated With Carotid Intima-Media Thickness in Healthy 50-Year-Old Men Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2422 - 2430. [Abstract] [Full Text] [PDF] |
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L. H. Kuller, K. A. Matthews, K. Sutton-Tyrrell, D. Edmundowicz, and C. H. Bunker Coronary and Aortic Calcification Among Women 8 Years After Menopause and Their Premenopausal Risk Factors : The Healthy Women Study Arterioscler Thromb Vasc Biol, September 1, 1999; 19(9): 2189 - 2198. [Abstract] [Full Text] [PDF] |
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R. Klein, L. Clegg, L. S. Cooper, L. D. Hubbard, B. E. K. Klein, W. N. King, A. R. Folsom, and for the Atherosclerosis Risk in Communities Study Prevalence of Age-related Maculopathy in the Atherosclerosis Risk in Communities Study Arch Ophthalmol, September 1, 1999; 117(9): 1203 - 1210. [Abstract] [Full Text] [PDF] |
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P. C. G. Simons, A. Algra, M. L. Bots, D. E. Grobbee, and Y. van der Graaf Common Carotid Intima-Media Thickness and Arterial Stiffness : Indicators of Cardiovascular Risk in High-Risk PatientsThe SMART Study (Second Manifestations of ARTerial disease) Circulation, August 31, 1999; 100(9): 951 - 957. [Abstract] [Full Text] [PDF] |
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P. H. Davis, J. D. Dawson, L. T. Mahoney, and R. M. Lauer Increased Carotid Intimal-Medial Thickness and Coronary Calcification Are Related in Young and Middle-Aged Adults : The Muscatine Study Circulation, August 24, 1999; 100(8): 838 - 842. [Abstract] [Full Text] [PDF] |
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S. Boquist, G. Ruotolo, R. Tang, J. Bjorkegren, M. G. Bond, U. de Faire, F. Karpe, and A. Hamsten Alimentary Lipemia, Postprandial Triglyceride-Rich Lipoproteins, and Common Carotid Intima-Media Thickness in Healthy, Middle-Aged Men Circulation, August 17, 1999; 100(7): 723 - 728. [Abstract] [Full Text] [PDF] |
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A. Festa, R. D'Agostino Jr, P. Rautaharju, D. H. O'Leary, M. Rewers, L. Mykkanen, and S. M. Haffner Is QT Interval a Marker of Subclinical Atherosclerosis in Nondiabetic Subjects? : The Insulin Resistance Atherosclerosis Study (IRAS) Stroke, August 1, 1999; 30(8): 1566 - 1571. [Abstract] [Full Text] [PDF] |
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K. Jensen-Urstad, M. Jensen-Urstad, and J. Johansson Carotid Artery Diameter Correlates With Risk Factors for Cardiovascular Disease in a Population of 55-Year-Old Subjects Stroke, August 1, 1999; 30(8): 1572 - 1576. [Abstract] [Full Text] [PDF] |
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B. M. McQuillan, J. P. Beilby, M. Nidorf, P. L. Thompson, and J. Hung Hyperhomocysteinemia but Not the C677T Mutation of Methylenetetrahydrofolate Reductase Is an Independent Risk Determinant of Carotid Wall Thickening : The Perth Carotid Ultrasound Disease Assessment Study (CUDAS) Circulation, May 11, 1999; 99(18): 2383 - 2388. [Abstract] [Full Text] [PDF] |
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C. Thalhammer, B. Balzuweit, A. Busjahn, C. Walter, F. C. Luft, and H. Haller Endothelial Cell Dysfunction and Arterial Wall Hypertrophy Are Associated With Disturbed Carbohydrate Metabolism in Patients at Risk for Cardiovascular Disease Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1173 - 1179. [Abstract] [Full Text] [PDF] |
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S. Ebrahim, O. Papacosta, P. Whincup, G. Wannamethee, M. Walker, A. N. Nicolaides, S. Dhanjil, M. Griffin, G. Belcaro, A. Rumley, et al. Carotid Plaque, Intima Media Thickness, Cardiovascular Risk Factors, and Prevalent Cardiovascular Disease in Men and Women : The British Regional Heart Study Stroke, April 1, 1999; 30(4): 841 - 850. [Abstract] [Full Text] [PDF] |
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P. B. Gorelick, R. L. Sacco, D. B. Smith, M. Alberts, L. Mustone-Alexander, D. Rader, J. L. Ross, E. Raps, M. N. Ozer, L. M. Brass, et al. Prevention of a First Stroke: A Review of Guidelines and a Multidisciplinary Consensus Statement From the National Stroke Association JAMA, March 24, 1999; 281(12): 1112 - 1120. [Abstract] [Full Text] [PDF] |
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P. Poredos, M. Orehek, E. Tratnik, and P. Poredos Smoking is Associated with Dose-Related Increase of Intima-Media Thickness and Endothelial Dysfunction Angiology, March 1, 1999; 50(3): 201 - 208. [Abstract] [PDF] |
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M. Zureik, P.-J. Touboul, C. Bonithon-Kopp, D. Courbon, C. Berr, C. Leroux, and P. Ducimetiere Cross-Sectional and 4-Year Longitudinal Associations Between Brachial Pulse Pressure and Common Carotid Intima-Media Thickness in a General Population : The EVA Study Stroke, March 1, 1999; 30(3): 550 - 555. [Abstract] [Full Text] [PDF] |
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M. Zureik, P.-J. Touboul, C. Bonithon-Kopp, D. Courbon, I. Ruelland, and P. Ducimetiere Differential Association of Common Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaques With Parental History of Premature Death From Coronary Heart Disease : The EVA Study Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 366 - 371. [Abstract] [Full Text] [PDF] |
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