American Journal of Epidemiology Vol. 134, No. 2: 111-122
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health
other |
Predictors of Arteriographically Defined Coronary Stenosis in the Honolulu Heart Program
Comparisons of Cohort and Arteriography Series Analyses
1Honolulu Heart Program, National Heart, Lung, and Blood Institute Bethesda, MD
2Honolulu Heart Program, Kuakini Medical Center Honolulu, HI
Reprint requests to Dr. Dwayne Reed, Honolulu Heart Program, 347 North Kuakini Street, Honolulu, HI 96817.
The purpose of this study was to determine if the major risk factors for clinical myocardial infarction also predicted coronary artery stenosis as defined by arteriography. Of a cohort of 7,591 men who were free of cardiovascular disease at entry, 357 had arteriographic studies during a 20-year follow-up period. Risk factor levels were therefore known prior to the onset of clinical symptoms and arteriographic studies. Men with arteriograms were divided into groups with and without prior clinical myocardial infarction. High blood pressure, serum cholesterol, obesity, and low alcohol intake predicted both severe coronary stenosis and incident myocardial infarction, thus indicating that these variables were associated with clinical events through the underlying process of atherosclerosis. Dietary intake of cholesterol and serum glucose also had similar but not always statistically significant patterns of association with both coronary stenosis and myocardial infarction. In contrast, serum triglyceride and cigarette smoking predicted clinical myocardial infarction, but not severe coronary stenosis. This suggests that these variables play a stronger rote in the precipitation of acute clinical events than in the underlying process of atherosclerosis. The findings were quite different for several risk factors when analyzed in a case-control format using the arteriography series from this same data set. Examination of possible explanations for the differences raises questions concerning the use of arteriography series for etiologic studies of coronary atherosclerosis. Am J Epidemiol 1991; 134: 111–22.
angiography; arteriosclerosis; bias (epidemiology); prospective studies; risk factors
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y.-M. Song and H.-J. Cho Risk of Stroke and Myocardial Infarction After Reduction or Cessation of Cigarette Smoking: A Cohort Study in Korean Men Stroke, September 1, 2008; 39(9): 2432 - 2438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Crouse III, R. Tang, M. A. Espeland, J. G. Terry, T. Morgan, and M. Mercuri Associations of Extracranial Carotid Atherosclerosis Progression With Coronary Status and Risk Factors in Patients With and Without Coronary Artery Disease Circulation, October 15, 2002; 106(16): 2061 - 2066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Delafontaine IRS-1 Variant : A New Risk Factor for Coronary Artery Disease? Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 283 - 284. [Full Text] [PDF]
|
|
|
|
|
|
M. G. Baroni, M. P. D’Andrea, A. Montali, G. Pannitteri, F. Barilla, F. Campagna, E. Mazzei, S. Lovari, F. Seccareccia, P. P. Campa, et al. A Common Mutation of the Insulin Receptor Substrate-1 Gene Is A Risk Factor for Coronary Artery Disease Arterioscler Thromb Vasc Biol, December 1, 1999; 19(12): 2975 - 2980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Marckmann, E.-M. Bladbjerg, and J. Jespersen Dietary Fish Oil (4 g Daily) and Cardiovascular Risk Markers in Healthy Men Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3384 - 3391. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Enriquez-Sarano, E. Klodas, K. N. Garratt, K. R. Bailey, A. J. Tajik, and D. R. Holmes Secular Trends in Coronary Atherosclerosis -- Analysis in Patients with Valvular Regurgitation N. Engl. J. Med., August 1, 1996; 335(5): 316 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Hlatky, L. C. Lam, K. L. Lee, N. E. Clapp-Channing, R. B. Williams, D. B. Pryor, R. M. Califf, and D. B. Mark Job Strain and the Prevalence and Outcome of Coronary Artery Disease Circulation, August 1, 1995; 92(3): 327 - 333. [Abstract] [Full Text]
|
|