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American Journal of Epidemiology Vol. 134, No. 10: 1212-1221
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Effects of Age, Breast Feeding, and Household Structure on Haemophilus influenzae Type b Disease Risk and Antibody Acquisition in Alaskan Eskimos

Gloria M. Petersen1, Diana R. Silimperi2, Chung-Yin Chiu3 and Joel I. Ward3,

1Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD
2Department of International Health, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD
3Department of Pediatrics, Harbor-UCUL Medical Center, UCLA School of Medicine Torrance, CA

Reprint requests to Dr Joel I Ward, UCLA Center for Vaccine Research, Harbor-UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90509

Invasive Haemophilus influenzae type b (Hib) disease occurs with unusually high incidence in Alaskan Eskimos. In 1983, the authors evaluated the unique susceptibility of the Yupik-speaking Eskimo population in southwest Alaska. A matched case-control design was used to assess the influence of age, breast feeding, and household composition on disease risk, with a historical cohort design to evaluate their effects on acquisition of Hib anticapsular antibody. The authors studied 103 cases with known invasive Hib disease that occurred at a mean age of 8.7 ± 8.6 months; healthy controls were matched for age and village of residence. Living in extended families at the time of disease onset was significantly associated with Hib disease (p < 0.04; odds ratio = 1.8; 95% confidence interval 0.87–3.25). The authors found that breast feeding was significantly less common among cases than controls (p < 0.03; odds ratio = 0.53; 95% confidence interval 0.27–0.98). Although there was a positive correlation between age and acquired level of total anticapsular antibody (r = 0.59; p < 0.0001), previous exposure to invasive Hib disease did not influence these levels. Household crowding and breast feeding also did not appear to affect Hib antibody acquisition. Am J Epidemiol 1991;134:1212–21.

antibodies; bacterial; breast feeding; Eskimos; Haemophilus influenzae; risk factors


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