American Journal of Epidemiology Vol. 134, No. 1: 39-48
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health
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The Impact of the Guidelines for a Healthy Diet of the Netherlands Nutrition Council on Total and High Density Lipoprotein Cholesterol in Hypercholesterolemic Free-living Men
From the Department of Epidemiology, National Institute of Public Health and Environmental Protection P O Box 1, 3720 BA Bilthoven, The Netherlands
Address reprint requests to Bennie P. M. Bloemberg, Department of Epidemiology, National Institute of Public Health and Environmental Protection, P O. Box 1, 3720 BA Bilthoven, The Netherlands.
To study the impact of dietary intervention on the plasma total and high density lipoprotein cholesterol (HDL cholesterol) levels in hypercholesterolemic men, the authors selected 80 male participants in a monitoring risk factor project carried out in Amsterdam, The Netherlands. These men had plasma total cholesterol levels of between 6.5 and 10.0 mmol/liter (between 251 and 387 mg/dl) and were randomly assigned to either the intervention (n = 39) or the control (n = 41) group. At the start of the intervention period, after 5 weeks, and after 26 weeks, both the intervention and the control groups were examined. This examination consisted of a measurement of height, weight, plasma total and HDL cholesterol, and a dietary interview. The intervention program consisted of a personalized dietary advice to the respondent, based on the report of the Netherlands Nutrition Council. The study took place between September 1987 and November 1988. Because of this intervention program, the plasma total and HDL cholesterol levels decreased. The difference in change in plasma total cholesterol between the intervention and control groups was 0.47 mmol/liter (18 mg/dl) after 5 weeks and 0.30 mmol/liter (12 mg/dl) after 26 weeks. For HDL cholesterol, a significant difference in change after 5 weeks disappeared after 26 weeks. The public health implications of the decrease in plasma total cholesterol are discussed. Am J Epidemiol 1991; 134: 39–48.
cholesterol; diet; lipoproteins; HDL cholesterol
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