American Journal of Epidemiology Vol. 133, No. 9: 884-899
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health
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Tracking of Serum Lipids and Lipoproteins from Childhood to Adulthood
The Bogalusa Heart Study
1 Department of Medicine, Louisiana State University Medical Center New Orleans, LA
2 Departments of Biometry and Genetics, Louisiana, State University Medical Center New Orleans, LA
3 Department of Biochemistry, Louisiana State University Medical Center New Orleans, LA
Address for reprints Dr Gerald S Berenson, Department of Medicine, LSU Medical Center, 1542 Tulane Avenue, New Orleans, LA 70112–2865
Serum lipids (total cholesterol and tnglycerides) and lipoprotein cholesterol fractions (low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol, and high density lipoprotein (HDL) cholesterol) have been measured approximately every 3 years on children and young adults since 1973–1974 in Bogalusa, Louisiana, a community of approximately 22,000 individuals, one-third of whom are black and two-thirds of whom are white. A total of 1,586 children were examined both at baseline (1973–1974) and at the most recent survey (1984–1986), providing 12 years of follow-up. The decreases in levels noted during puberty for total cholesterol and LDL cholesterol, primarily for boys, were followed by a nse until age 26 years. HDL cholesterol levels, particularly for white boys, continued to drop after age 14 years, yielding increasingly high LDL cholesterol/HDL cholesterol ratios. Tracking, as measured by both correlation coefficients and persistence at extreme quartiles, was evident for all of the lipids and lipoproteins. The 12-year correlation coefficients were greatest for LDL cholesterol and no trend in the magnitude of the correlation coefficients with age was noted. Tracking for HDL cholesterol was better after age 9 years, particularly for white males. Approximately 50% of those children who had total cholesterol levels or LDL cholesterol levels above the 75th percentile at baseline remained elevated 12 years later. For HDL cholesterol, a trend with age was noted for white boys: 42% of those aged 9–14 years in the lowermost quartile persisted in this rank 12 years later. The best predictor of follow-up lipid or lipoprotein level was baseline level. The next best predictor was increase in weight as defined by weight/height3, an index of obesity. That serum lipid and lipoprotein levels continue to track from childhood into young adulthood points to the necessity of measurement early in life and, where indicated, the introduction of preventive and interventional programs aimed at developing healthy lifestyles. Am J Epidemiol 1991; 133: 884–99.
coronary disease; lipids; lipoproteins; longitudinal studies; risk factors
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|
|
|
|
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|
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|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
P. O. Kwiterovich Jr, B. A. Barton, R. P. McMahon, E. Obarzanek, S. Hunsberger, D. Simons-Morton, S. Y. S. Kimm, L. A. Friedman, N. Lasser, A. Robson, et al. Effects of Diet and Sexual Maturation on Low-Density Lipoprotein Cholesterol During Puberty : The Dietary Intervention Study in Children (DISC) Circulation, October 21, 1997; 96(8): 2526 - 2533. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
 |
|
 W. Bao, S. R. Srinivasan, W. A. Wattigney, W. Bao, and G. S. Berenson Usefulness of Childhood Low-Density Lipoprotein Cholesterol Level in Predicting Adult Dyslipidemia and Other Cardiovascular Risks: The Bogalusa Heart Study Arch Intern Med, June 24, 1996; 156(12): 1315 - 1320. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
T. E Forrester, R. J Wilks, F. I Bennett, D. Simeon, C. Osmond, M. Allen, A. P Chung, and P. Scott Fetal growth and cardiovascular risk factors in Jamaican schoolchildren BMJ, January 20, 1996; 312(7024): 156 - 156. [Abstract] [Full Text]
|
|
|
|
 |
|
 Council on Scientific Affairs Management of Disorders of Cholesterol, Triglyceride, and Lipoprotein Metabolism: Report 6 of the Council on Scientific Affairs Arch Fam Med, October 1, 1995; 4(10): 869 - 878. [Abstract] [PDF]
|
|
|
|
|
|
I. Benuck, S. S. Gidding, and M. Donovan Year-to-Year Variability of Cholesterol Levels in a Pediatric Practice Arch Pediatr Adolesc Med, March 1, 1995; 149(3): 292 - 296. [Abstract] [PDF]
|
|
|
|
|
|
X. Jiang, S. R. Srinivasan, L. S. Webber, W. A. Wattigney, and G. S. Berenson Association of Fasting Insulin Level With Serum Lipid and Lipoprotein Levels in Children, Adolescents, and Young Adults: The Bogalusa Heart Study Arch Intern Med, January 23, 1995; 155(2): 190 - 196. [Abstract] [PDF]
|
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|
|
|
|
W. Bao, S. R. Srinivasan, W. A. Wattigney, and G. S. Berenson Persistence of Multiple Cardiovascular Risk Clustering Related to Syndrome X From Childhood to Young Adulthood: The Bogalusa Heart Study Arch Intern Med, August 22, 1994; 154(16): 1842 - 1847. [Abstract] [PDF]
|
|
|
|
|
|
S. S. Gidding The Rationale for Lowering Serum Cholesterol Levels in American Children Arch Pediatr Adolesc Med, April 1, 1993; 147(4): 386 - 392. [Abstract] [PDF]
|
|