American Journal of Epidemiology Vol. 133, No. 8: 832-838
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Repeat Measurement of Case-Control Data: Correcting Risk Estimates for Misclassification Due to Regression Dilution of Lipids in Transient Ischemic Attacks and Minor Ischemic Strokes
1University Department of Medicine The General Infirmary, Leeds, United Kingdom
2Medical Research Council Biostatistics Unit Cambridge, United Kingdom
3National Cancer Institute of Canada Epidemiology Unit, Faculty of Medicine, University of Toronto Toronto, Ontario, Canada
Reprint requests to Dr. Nawab Qizilbash, Department of Medicine, The Martin Wing, The General Infirmary, Leeds LS1 3EX, United Kingdom.
In a case-control study to determine the role of lipids as risk factors for ischemic cerobravascular disease, 105 cases of transient ischemic attacks and minor ischemic strokes were compared with 241 controls. Recruitment to the study took place in Oxford, United Kingdom, in 1986 and 1987. In a random subset of 100 of the original controls, repeat assays of total cholesterol, low density lipoprotein cholesterol, (LDL cholesterol), and high density lipoprotein cholesterol (HDL cholesterol) were performed. With maximum likelihood theory, the repeat data were used to produce odds ratio estimates of relative risk corrected for mismeasurement. Uncorrected odds ratios associated with total cholesterol of more than 6 mmol/liter, LDL cholesterol of more than 3.5 mmol/liter, and HDL cholesterol of more than 1.2 mmol/liter were, respectively, 2.06 (95% confidence interval (CI) 1.26–3.37), 2.02 (95% CI 1.24–3.30), and 0.46 (95% CI 0.28–0.74). Corrected for mismeasurement, the corresponding odds ratios were 2.90 (95% CI 1.42–5.93), 2.57 (95% CI 1.24–5.32), and 0.36 (95% CI 0.17–0.71), respectively. The attributable risks changed from 34 to 48% for total cholesterol, from 34 to 43% for LDL cholesterol, and from 35 to 45% for HDL cholesterol. The maximum likelihood procedure described here corrects for substantial underestimation of the strength of an association and indicates the need to obtain repeat measurements on variables which are subject to random fluctuation. Am J Epidemiol 1991 ;133:832–8.
case-control studies; likelihood functions; stroke
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. R Emberson, P. H Whincup, R. W Morris, and M. Walker Social class differences in coronary heart disease in middle-aged British men: implications for prevention Int. J. Epidemiol., April 1, 2004; 33(2): 289 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Holford and C. Stack Study design for epidemiologic studies with measurement error Statistical Methods in Medical Research, December 1, 1995; 4(4): 339 - 358. [Abstract] [PDF]
|
|