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American Journal of Epidemiology Vol. 133, No. 8: 757-765
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health

other

Assessment of Family History Information in Case-Control Cancer Studies

Pamela H. Phillips1,3,, Martha S. Linet2 and Emily L. Harris3

1The EMMES Corporation Potomac, MD
2Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute Bethesda, MD
3Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD.

Reprint requests to Pamela H Phillips, The EMMES Corporation, 11325 Seven Locks Road, Suite 214, Potomac, MD 20854.

Evidence for the genetic basis of cancer has increased in recent years, and thus, assessing familial aggregation may play an important role in epidemiologic studies. To assess the degree to which family history variables are collected in cancer case-control studies, the authors conducted a literature review of studies published in six journals during 1982–1984. Only 25% of these included a family history component. The authors review some of the literature in favor of inclusion of family information and argue for its routine collection in cancer case-control studies. Am J Epidemiol 1991 ;133:757–65.

case-control studies; genetics; biochemical; neoplastic syndromes; hereditary


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