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American Journal of Epidemiology Vol. 133, No. 12: 1220-1230
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Risk Factors for Mortality from All Causes and from Coronary Heart Disease among Persons with Diabetes

Findings from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study

Earl S. Ford and Frank DeStefano

From the Division of Diabetes Translation, Center for Chronic Disease Prevention and Health Promoton, Centers for Disease Control 1600 Clifton Road NE, Mailstop K10, Atlanta, GA 30333

Coronary heart disease is the leading cause of mortality among persons with diabetes mellitus, but the factors that account for this high coronary heart disease mortality remain unclear. In the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study, conducted from 1982 to 1984, 92 deaths from coronary heart disease were found to have occurred among 602 diabetic participants and 558 deaths from coronary heart disease were found to have occurred among 12,562 nondiabetic participants during follow-up period (1971–1984; average follow-up, 10 years). Using proportional hazards analysis, the authors found age, male sex, severe overweight, and non-leisure-time physical inactivity to be significantly associated with coronary heart disease mortality among persons with diabetes. Age, male sex, current smoking, hypertension, and non-leisure-time physical inactivity were associated with all-cause morality. Cholestral showed a more complex relation to all-cause morality. The strength of the associations between risk factors and all-cause and coronary heart disease mortality did not differ significantly among persons with and without diabetes. These results reinforce the important of controlling coronary heart disease risk factors among person with diabetes.

cholesterol; coronary disease; diabetes mellitus; exertion; hypertension; mortality; obesity; smoking


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