American Journal of Epidemiology Vol. 132, No. 6: 1111-1119
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
PERINATAL RISK FACTORS FOR INFLAMMATORY BOWEL DISEASE: A CASE-CONTROL STUDY
1Department of Surgery, Unit of Cancer Epidemiology, University Hospital Uppsala, Sweden
2Aging and Statistics Branch, Division of Chronic Disease Control and Community Intervention, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control Atlanta, GA
3Department of Pediatrics, University Hospital Uppsala, Sweden
Reprint requests to Dr. Anders Ekbom, Department of Surgery, University Hospital, S-75 1 85, Uppsala, Sweden
To examine perinatal risk factors for Crohn's disease and ulcerative colitis, the authors analyzed birth records for 257 known case participants delivered from 1924 through 1957 at the University Hospital in Uppsala County, Sweden, and compared them with records for 514 controls delivered at the hospital. The two groups were matched by date of birth, sex, and either maternal age or parity. Eleven study variables were abstracted from standard forms that recorded health events during the pregnancy and the delivery hospitalization. Participants were more likely than controls to have a recorded health event (odds ratio (OR) = 4.4; 95% confidence interval (Cl) 3.0–6.4). In a multivarlate model, this increased risk was evident for infectious (OR = 3.8; 95% Cl 2.6–5.8) and noninfectious (OR = 3.5; 95% Cl 2.0–6.3) events. Perinatal health events may have contributed to 40% of the inflammatory bowel disease cases in our study. Infants from families with low socioeconomic status had greater risk of inflammatory bowel disease than did infants from families with high socioeconomic status (OR = 3.0, 95% Cl 1.5– 8.1). Perinatal health events and low socioeconomic status independently in creased the risk of inflammatory bowel disease.
colitis, ulcerative; Crohn disease; Crohn disease, etiology; infection; inflammatory bowel diseases; pregnancy complications, Infectious; risk factors; social class
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C Carlens, L Jacobsson, L Brandt, S Cnattingius, O Stephansson, and J Askling Perinatal characteristics, early life infections and later risk of rheumatoid arthritis and juvenile idiopathic arthritis Ann Rheum Dis, July 1, 2009; 68(7): 1159 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Green, L. Elliott, C. Beaudoin, and C. N. Bernstein A Population-based Ecologic Study of Inflammatory Bowel Disease: Searching for Etiologic Clues Am. J. Epidemiol., October 1, 2006; 164(7): 615 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Baron, D Turck, C Leplat, V Merle, C Gower-Rousseau, R Marti, T Yzet, E Lerebours, J-L Dupas, S Debeugny, et al. Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study Gut, March 1, 2005; 54(3): 357 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Klement, R. V Cohen, J. Boxman, A. Joseph, and S. Reif Breastfeeding and risk of inflammatory bowel disease: a systematic review with meta-analysis Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1342 - 1352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Seril, J. Liao, G.-Y. Yang, and C. S. Yang Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models Carcinogenesis, March 1, 2003; 24(3): 353 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L M Kurina, M J Goldacre, D Yeates, and V Seagroatt Appendicectomy, tonsillectomy, and inflammatory bowel disease: a case-control record linkage study J Epidemiol Community Health, July 1, 2002; 56(7): 551 - 554. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. L. Davis, P. Kramarz, K. Bohlke, P. Benson, R. S. Thompson, J. Mullooly, S. Black, H. Shinefield, E. Lewis, J. Ward, et al. Measles-Mumps-Rubella and Other Measles-Containing Vaccines Do Not Increase the Risk for Inflammatory Bowel Disease: A Case-Control Study From the Vaccine Safety Datalink Project Arch Pediatr Adolesc Med, March 1, 2001; 155(3): 354 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A EKBOM and P WATSON Appendicectomy and childhood hygiene: different sides of the same coin? Gut, October 1, 1998; 43(4): 451 - 451. [Full Text]
|
|
|
|
|
|
A E Duggan, I Usmani, K R Neal, and R F A Logan Appendicectomy, childhood hygiene, Helicobacter pylori status, and risk of inflammatory bowel disease: a case control study Gut, October 1, 1998; 43(4): 494 - 498. [Abstract] [Full Text] [PDF]
|
|