American Journal of Epidemiology Vol. 132, No. 4: 746-748
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
DOES NONDIFFERENTIAL MISCLASSIFICATION OF EXPOSURE ALWAYS BIAS A TRUE EFFECT TOWARD THE NULL VALUE?
From the Epidemiology and Biostatistics Program, National Cancer Institute Rockville, MD
Reprint requests to Dr. Mustafa Dosemeci, Occupational Studies Section, Epidemiology and Biostatistics Branch, National Cancer Institute, NIH, Building EPN, Room 418, Rockville, MD 20892.
The authors present some examples to demonstrate that in certain nondifferential misclassification conditions with polychotomous exposure variables, estimates of odds ratios for categories at intermediate level of risk can be biased away from the null or can change direction. In addition, the authors present two examples to demonstrate that the slope of the dose-response trend for the true distributions can change direction, creating a false inverse trend, even if the misclassification is nondifferential.
bias; case-control studies; dose-response trend; epidemiologic methods; misclassification; nondifferential
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