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American Journal of Epidemiology Vol. 132, No. 4: 717-722
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

research-article

COFACTORS OF PROGRESSION TO ACQUIRED IMMUNODEFICIENCY SYNDROME IN A COHORT OF MALE SEXUAL CONTACTS OF MEN WITH HUMAN IMMUNODEFICIENCY VIRUS DISEASE

RANDALL A. COATES1,2,, VERNON T. FAREWELL1,3, JANET RABOUD1, STANLEY E. READ2,4, DOUGLAS K. MACFADDEN2, LIVIANA M. CALZAVARA1, J. KENNETH JOHNSON1, FRANCES A. SHEPHERD2 and MARY M. FANNING2

1Department of Preventive Medicine and Biostatistics, Faculty of Medicine, University of Toronto Toronto, Ontario, Canada
2Department of Medicine, Faculty of Medicine, University of Toronto Toronto, Ontario, Canada
3Departments of Statistics and Actuarial Science and Health Studies, University of Waterloo Waterloo, Ontario, Canada
4Department of Pediatrics, Faculty of Medicine, University of Toronto Toronto, Ontario, Canada

Reprint requests to Dr. Randall Coates, Department of Preventive Medicine and Biostatistics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8

In a cohort of 249 male sexual contacts of men with acquired immunodeficiency syndrome (AIDS) or an AIDS-related condition in Toronto, Ontario, Canada, 143 cohort members were seropositive on enrollment and 16 seroconverted between initial recruitment in July 1984 to July 1985 and December 1988. Data on age, smoking and drinking status, recreational drug use, and history of sexually transmitted diseases and other diseases were obtained from interviews at induction and during follow-up on the cohort members every 3 months. Cox relative risk regression models, in which time was calculated from estimated date of human immunodeficiency virus (HIV) infection for seroprevalent cohort members and from 90 days prior to the first positive test for seroconverters, examined the potential effect of use of a variety of recreational drugs and the occurrence of selected infections on the risk of development of AIDS. Thirty-five cohort members developed AIDS while under study. No significant association with risk of progression to AIDS was noted for use of various recreational drugs (singly or in combination), history of specific infections, age at enrollment, or smoking and drinking status at enrollment. Only estimated duration of HIV infection appeared to be associated with increasing risk of development of AIDS.

acquired immunodeficiency syndrome; cohort studies; HIV


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