American Journal of Epidemiology

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American Journal of Epidemiology Vol. 132, No. 4: 612-628
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

review-article

A META-ANALYSIS OF PHYSICAL ACTIVITY IN THE PREVENTION OF CORONARY HEART DISEASE

JESSE A. BERLIN^1,2, and GRAHAM A. COLDITZ^1,3

¹Technology Assessment Group, Harvard School of Public Health Boston, MA
²University of Pennsylvania School of Medicine, Section of General Internal Medicine, Clinical Epidemiology Unit Philadelphia, PA
³Channing Laboratory, Harvard Medical School Boston, MA

Reprint requests to Dr. Jesse A. Berlin, University of Pennsylvania School of Medicine, Clinical Epidemiology Unit, 331 R Nursing Education Building, Philadelphia, PA 19104-6095.

Evidence for an independent role of increased physical activity in the primary prevention of coronary heart disease has grown in recent years. The authors apply the techniques of meta-analysis to data extracted from the published literature by Powell et al. (Ann Rev Public Health 1987;8:253–87), as well as more recent studies addressing this relation, in order to make formal quantitative statements and to explore features of study design that influence the observed relation between physical activity and coronary heart disease risk. They find, for example, a summary relative risk of death from coronary heart disease of 1.9 (95% confidence interval 1.6–2.2) for sedentary compared with active occupations. The authors also find that methodologically stronger studies tend to show a larger benefit of physical activity than less well-designed studies.

coronary disease; exercise; meta-analysis

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