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American Journal of Epidemiology Vol. 132, No. 3: 446-452
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE INCIDENCE OF OVARIAN CANCER IN SWEDEN, 1960–1984

HANS-OLOV ADAMI1,, REINHOLD BERGSTRÖM2, INGEMAR PERSSON3 and PÄR SPARÉN4

1Department of Surgery, University Hospital Uppsala, Sweden
2Department of Statistics, Uppsala University Uppsala, Sweden
3Department of Gynecology and Obstetrics, University Hospital Uppsala, Sweden
4Swedish Cancer Registry, National Board of Health and Welfare Stockholm, Sweden

Reprint requests to Dr. Hans-Olov Adami, Department of Surgery, University Hospital, S-751 85 Uppsala, Sweden

Trends in the incidence of ovarian cancer among 23,239 cases reported to the Swedish Cancer Registry from 1960 through 1984 were analyzed. Trends in age-standardized incidence rates were best described by a nonlinear model with a highly significant negative second-order term, which showed an initial increase followed by stabilization and, in later years, a decline. In multivariate models, both time period of diagnosis and birth cohort were found to have significant effects. These separate models provided consistent evidence for an increasing risk in women born during the last decades of the 19th century, and a slowly decreasing risk in recent years and in the youngest birth cohorts. The very high population exposure to oral contraceptives, which may protect against ovarian cancer, is one conceivable explanation for the decreasing trend.

age factors; models, statistical; ovarian neoplasms; statistics; time


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