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American Journal of Epidemiology Vol. 132, No. 2: 304-309
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

research-article

INTERPREGNANCY INTERVAL AND RISK OF PRETERM LABOR

JANET M. LANG1, ELLICE LIEBERMAN2,3, KENNETH J. RYAN2 and RICHARD R. MONSON4

1Epidemiology and Biostatistics Section, Boston University School of Public Health Boston, MA
2Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School Boston, MA
3Department of Maternal and Child Health, Harvard School of Public Health Boston, MA
4Department of Epidemiology, Harvard School of Public Health Boston, MA

Reprint requests to Dr. Janet M. Lang, Epidemiology and Biostatistics Section, Boston University School of Public Health, 80 East Concord Street, Boston, MA 02118-2394

In 1977–1980, over 12,000 pregnant women being followed at the Boston Hospital for Women were interviewed and had their medical records reviewed. The effect of interpregnancy interval on the risk of preterm labor was estimated in 4,467 of these women whose previous pregnancy had resulted in a full-term live birth. The rate of preterm birth after the spontaneous onset of labor in this cohort was 3.8 percent While the possibility of an increased risk of preterm labor for Interpregnancy intervals of 3 months or less cannot be definitely excluded (adjusted odds ratio=2.0, 95 percent confidence interval 0.7–5.4), no relation was found between other interpregnancy intervals and the risk of preterm labor. Earlier work from this same cohort showed a strong negative association between interpregnancy interval and small-for-gestational-age birth. Combining this with the results from the present study reinforces the importance of differentiating low birth weight due to preterm birth from that due to Intrauterine growth retardation.

Infant; low birth weight; infant, premature; labor, premature; pregnancy outcome


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