Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (68)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by WILKINS, J. R.
Right arrow Articles by SINKS, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WILKINS, J. R., III
Right arrow Articles by SINKS, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 132, No. 2: 275-292
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PARENTAL OCCUPATION AND INTRACRANIAL NEOPLASMS OF CHILDHOOD: RESULTS OF A CASE-CONTROL INTERVIEW STUDY

J. R. WILKINS, III1 and THOMAS SINKS1 2

1Department of Preventive Medicine, Ohio State University Columbus, OH

Reprint requests to Dr. J. R. Wilkins III, Department of Preventive Medicine, Ohio State University, 320 West 10th Avenue, Columbus, OH 43210-1240

In 1983–1984, the authors conducted a case-control study of environmental factors and childhood brain tumor risk. Cases (n=110) were identified through the tumor registry of a pediatric hospital and matched controls (n=193) through random digit dialing. In addition to parental occupational histories, telephone Interviews elicited information about potential confounders and hypothesized risk factors for childhood brain tumors. Relying primarily on the Hoar et al. (J Occup Med 1980;22:722-6) job-exposure matrix, the authors examined parental employment characteristics in relation to the relevant developmental periods. Paternal employment in several industries (agriculture, construction, metal, and food and tobacco) and in several occupations (agriculture, benchwork, and transportation) was associated with excess risk. The range of notably elevated odds ratios was 2.0–3.3, with all confidence intervals including 1.0 except one. Elevated but unstable odds ratios were also found for both paternal and maternal employment in jobs clustered together because of common exposures. For both approaches to exposure classification, the greatest excess risks were consistently demonstrated for parental jobs held in the preconception period. Job-exposure matrix analyses indicated that case fathers were more likely than control fathers to have had jobs linked with aromatic amino and aromatic nitro compounds (range of notably elevated (and unstable) odds ratios, 3.4–4.4), but here the greatest excess risks were exhibited in the postnatal period. Few associations emerged for maternal employment characteristics, although this is probably explained by the relatively small number of women employed in jobs outside the home.

brain neoplasms; carcinogens; environmental; child; environmental exposure; occupational medicine

2Current address: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health Cincinnati, OH


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
S. E. Puumala, L. G. Spector, L. L. Robison, G. R. Bunin, A. F. Olshan, A. M. Linabery, M. A. Roesler, C. K. Blair, and J. A. Ross
Comparability and Representativeness of Control Groups in a Case-Control Study of Infant Leukemia: A Report From the Children's Oncology Group
Am. J. Epidemiol., August 1, 2009; 170(3): 379 - 387.
[Abstract] [Full Text] [PDF]

Home page
 Neuro Oncol DukeHome page
Z. Fang, M. Kulldorff, and D. I. Gregorio
Brain cancer mortality in the United States, 1986 to 1995: A geographic analysis
Neuro-oncol, July 1, 2004; 6(3): 179 - 187.
[Abstract] [PDF]

Home page
 Am J EpidemiolHome page
S. Cordier, C. Monfort, G. Filippini, S. Preston-Martin, F. Lubin, B. A. Mueller, E. A. Holly, R. Peris-Bonet, M. McCredie, W. Choi, et al.
Parental Exposure to Polycyclic Aromatic Hydrocarbons and the Risk of Childhood Brain Tumors: The SEARCH International Childhood Brain Tumor Study
Am. J. Epidemiol., June 15, 2004; 159(12): 1109 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
E. van Wijngaarden, P. A. Stewart, A. F. Olshan, D. A. Savitz, and G. R. Bunin
Parental Occupational Exposure to Pesticides and Childhood Brain Cancer
Am. J. Epidemiol., June 1, 2003; 157(11): 989 - 997.
[Abstract] [Full Text] [PDF]

Home page
 Indoor and Built EnvironmentHome page
A. J. Thornton and P. N. Lee
Review : Parental Smoking and Risk of Childhood Cancer: A Review of the Evidence
Indoor and Built Environment, March 1, 1998; 7(2): 65 - 86.
[Abstract] [PDF]

Home page
 Toxicol Ind HealthHome page
G. L. Gist and J. A. R. Burg
Trichloroethylene -- a Review of the Literature From a Health Effects Perspective
Toxicology and Industrial Health, May 1, 1995; 11(3): 253 - 307.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.