American Journal of Epidemiology Vol. 131, No. 3: 517-521
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health
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PATERNAL OCCUPATION AND ANENCEPHALY
1Environmental Epidemiology Program, Texas Department of Health Austin, TX
2Bureau of Disease Control and Epidemiology, Texas Department of Health Austin, TX
Reprint requests to Dr. Jean D. Brender, Environmental Epidemiology Program, Texas Department of Health, 1100 West 49th Street, Austin, TX 78756
It has been suggested that paternal occupational exposures to pesticides and solvents increase the risk of neural tube defects in offspring. With the use of Texas livebirth, fetal death, and linked livebirth-death records, the authors conducted a population-based case-control study among 19811986 Texas births to examine the association between paternal occupation and anencephalic births. Fathers employed in occupations associated with solvent exposure were more likely to have offspring with anencephaly (odds ratio (OR) = 2.53), with painters having the highest risk (OR = 3.43). A lesser association was found for fathers employed in occupations involving pesticide exposure (OR = 1.28). Further studies are indicated to clarify these associations.
abnormalities; anencephaly; environmental exposure
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