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American Journal of Epidemiology Vol. 131, No. 3: 395-399
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

research-article

SEX RATIO OF HUMAN T-LYMPHOTROPIC VIRUS TYPE I INFECTION AND BLOOD TRANSFUSION

MICHEL CHAVANCE1,, NADINE FRERY1, IGNEZ VALETTE2, LAURENCE SCHAFFAR-DESHAYES3 and NICOLE MONPLAISIR2

1INSERM U169 Villejuif, France
2Centre de Transfusion Sanguine Fort-de-France, Martinique
3INSERM U210 Nice, France

Reprint requests to Michel Chavance, INSERM U169, 16 avenue Paul Vaillant-Couturier, F94807 Villejuif, France

The prevalence of human T-lymphotropic virus type I (HTLV-I) infection is higher for females than for males. Blood transfusion is a potential confounding factor which might contribute to this high female:male ratio. Two studies were performed in Martinique (French West Indies) to clarify this issue: a case-control survey comparing the experience of previous blood transfusion among 62 HTLV-I-seropositive and 88 HTLV-I-seronegative blood donors, and a retrospective study of the sex of recipients of blood. Blood transfusion was strongly associated with HTLV-I infection (odds ratio = 6.4, p < 0.001). Females were more often given blood transfusions (57.9 percent, p < 0.001) and received a higher percentage of blood units (53.5 percent, p < 0.05) than could be expected from their proportion in the general population (51.6 percent). Thus, the high female:male sex ratio of HTLV-I-infected subjects might be due partially to a sex difference for blood transfusion.

blood transfusion; HTLV-I; HTLV-I infections; sex


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