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American Journal of Epidemiology Vol. 131, No. 1: 48-56
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE EPIDEMIOLOGY OF IDIOPATHIC DILATED CARDIOMYOPATHY IN A BIRACIAL COMMUNITY

STEVEN S. COUGHLIN1 4,, MOYSES SZKLO1, KENNETH BAUGHMAN2 and THOMAS A. PEARSON3

1Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD
2Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine Baltimore, MD
3Mary Imogene Bassett Research Institute Cooperstown, NY

Reprint requests to Dr. Steven S. Coughlin, Division of Biostatistics and Epidemiology, Kober Cogan Hall, Room 404, Georgetown University School of Medicine, Washington, DC 20007

An epidemiologic study of idiopathic dilated cardiomyopathy was carried out in order to identity possible risk factors for this often fatal cause of heart failure in young adults. Possible associations with black race and other genetic and environmental factors were examined by comparing newly diagnosed cases ascertained from four Baltimore hospitals (n=95) with neighborhood controls (n=95), matched on sex and 5-year age intervals. Matched and unmatched relative odds and conditional logistic regression coefficients were obtained to describe the associations. Statistically significant, independent associations were observed between idiopathic dilated cardiomyopathy and black race, low annual income, and history of asthma (p <0.05). The black predominance (relative odds=2.7, 95% confidence interval 2.0–3.4) was not explained by income, alcohol consumption, cigarette usage, body mass index, hypertension, or asthma. A possible interactive eftect was observed between black race and history of asthma and other atopic diseases. Thus, blacks, especially those with a history of hypersensitivity, may represent a high-risk subgroup in need of preventive care or early intervention.

alcohol, ethyl; asthma; blacks; cardiomyopathy, congestive; hypersensitivity; hypertension; obesity; smoking

4Current address: Division of Biostatistics and Epidemiology, Georgetown University School of Medicine, Washington, DC


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