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American Journal of Epidemiology Vol. 131, No. 1: 177-184
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

research-article

SAMPLE SIZE REQUIREMENTS FOR INTERVAL ESTIMATION OF THIS ODDS RATIO

GLEN A. SATTEN and LAWRENCE L. KUPPER

Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill CB 7400, Chapel Hill, NC 27599-7400

From the Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill, CB 7400, Chapel Hill, NC 27599-7400. (Reprint requests to Dr. Lawrence L. Kupper at this address.)

Sample sizes are calculated for unmatched case-control (or cohort) studies where the goal is interval estimation of the odds ratio. The procedure used gives the smallest sample size for which a 100(1-{alpha})% confidence interval for the log odds ratio will not exceed a specified width with specified probability (1-{gamma}). Tables of sample sizes for various choices of parameter values are presented. Considerable disagreement is found with a published method which has as its basis expected cell counts.

epidemiologic methods; probabillty; retrospective studies; statistics


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