American Journal of Epidemiology Vol. 131, No. 1: 169-176
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health
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NESTED CASE-CONTROL AND CASE-COHORT METHODS OF SAMPLING FROM A COHORT: A CRITICAL COMPARISON1
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The recently developed case-cohort method of sampling from a cohort is compared with the nested case-control method. Corrected asymptotic relative efficiency results show that the case-cohort design for single "disease" outcomes offers less improvement for intervention trials for which there is no random censoring than originally suggested. Furthermore, simulation results indicate that if there is moderate random censoring or staggered entry, the case-cohort method can do substantially worse than the nested case-control method.
biometry; epidemiologic methods; follow-up studies; research design; statistics
1From the Department of Preventive Medicine, University of Southern California, School of Medicine, 2025 Zonal Avenue, Los Angeles, CA 90033-9987.
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