American Journal of Epidemiology Vol. 130, No. 6: 1167-1175
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
PREVALENCE, INCIDENCE, AND PROGRESSION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN HOMOSEXUAL AND BISEXUAL MEN IN HEPATITIS B VACCINE TRIALS, 1978–1988
1AIDS Office, Department of Public Health City and County of San Francisco, San Francisco, CA
2AIDS Program, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services Atlanta, GA
Reprint requests to Nancy A. Hessol, AIDS Office, San Francisco Department of Public Health, 25 Van Ness, Suite 500, San Francisco, CA 94102
Between 1978 and 1980,359 hepatitis B seronegative homosexual and bisexual men were recruited from the San Francisco municipal sexually transmitted disease clinic for hepatitis B vaccine trials. Of the 359 participants, 320 (89%) consented to have their stored blood samples tested for human immunodeficiency virus antibodies. The prevalence of human immunodeficiency virus infection in these 320 vaccine trial participants rose from 0.3% in 1978 to 50.9% in 1988. The annual incidence of human immunodeficiency virus infection showed that seroconversion peaked in 1980-1982, dropped significantly in 1983, and has remained low. Men < 30 years old on entry into the study seroconverted earlier in the epidemic and had higher incidence rates than men 30 years or older (p = 0.07). No statistical difference in seroconversion rates was found for other demographic variables. Using a Kaplan-Meier survival curve of the cumulative proportion of men without acquired immunodeficiency syndrome by duration of human immunodeficiency virus infection, an estimated 39% (95% confidence interval 27%–51%) will develop acquired immunodeficiency syndrome within 9.2 years of infection. Cox proportional hazard stepwise analysis showed no correlation between age at seroconversion, race, or year of seroconversion and progression to acquired immunodeficiency syndrome.
acquired immunodeficiency syndrome; homosexuality; HIV
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. L. Stoneburner and D. Low-Beer Population-Level HIV Declines and Behavioral Risk Avoidance in Uganda Science, April 30, 2004; 304(5671): 714 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Valleroy, D. A. MacKellar, J. M. Karon, D. H. Rosen, W. McFarland, D. A. Shehan, S. R. Stoyanoff, M. LaLota, D. D. Celentano, B. A. Koblin, et al. HIV Prevalence and Associated Risks in Young Men Who Have Sex With Men JAMA, July 12, 2000; 284(2): 198 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lindback, C. Brostrom, A. Karlsson, and H. Gaines Does symptomatic primary HIV-1 infection accelerate progression to CDC stage IV disease, CD4 count below 200 x 106/l, AIDS, and death from AIDS? BMJ, December 10, 1994; 309(6968): 1535 - 1537. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Eskild, P. Magnus, C. Sohlberg, F. Jensen, and P. Kittelsen A Comparison of the Progression Rate to Acquired Immunodeficiency Syndrome between Intravenous Drug Users and Homosexual Men Scand J Public Health, December 1, 1994; 22(4): 309 - 314. [Abstract] [PDF]
|
|
|
|
|
|
G. F. Lemp, A. M. Hirozawa, D. Givertz, G. N. Nieri, L. Anderson, M. L. Lindegren, R. S. Janssen, and M. Katz Seroprevalence of HIV and Risk Behaviors Among Young Homosexual and Bisexual Men: The San Francisco/Berkeley Young Men's Survey JAMA, August 10, 1994; 272(6): 449 - 454. [Abstract] [PDF]
|
|
|
|
 |
|
 N. A. Hessol, M. H. Katz, J. Y. Liu, S. P. Buchbinder, C. J. Rubino, and S. D. Holmberg Increased Incidence of Hodgkin Disease in Homosexual Men with HIV Infection Ann Intern Med, August 15, 1992; 117(4): 309 - 311. [Abstract] [PDF]
|
|
|
|
 |
|
 M. H. Katz, A. B. Bindman, D. Keane, and A. K. Chan CD4 Lymphocyte Count as an Indicator of Delay in Seeking Human Immunodeficiency Virus--Related Treatment Arch Intern Med, July 1, 1992; 152(7): 1501 - 1504. [Abstract] [PDF]
|
|
|
|
|
|
R Brookmeyer Reconstruction and future trends of the AIDS epidemic in the United States Science, July 5, 1991; 253(5015): 37 - 42. [Abstract] [PDF]
|
|
|
|
|
|
T. V. Ellerbrock, T. J. Bush, M. E. Chamberland, and M. J. Oxtoby Epidemiology of Women With AIDS in the United States, 1981 Through 1990: A Comparison With Heterosexual Men With AIDS JAMA, June 12, 1991; 265(22): 2971 - 2975. [Abstract] [PDF]
|
|
|
|
|
|
M. Gwinn, M. Pappaioanou, J. R. George, W. H. Hannon, S. C. Wasser, M. A. Redus, R. Hoff, G. F. Grady, A. Willoughby, A. C. Novello, et al. Prevalence of HIV Infection in Childbearing Women in the United States: Surveillance Using Newborn Blood Samples JAMA, April 3, 1991; 265(13): 1704 - 1708. [Abstract] [PDF]
|
|
|
|
|
|
G. F. Lemp, S. F. Payne, G. W. Rutherford, N. A. Hessol, W. Winkelstein Jr, J. A. Wiley, A. R. Moss, R. E. Chaisson, R. T. Chen, D. W. Feigal Jr, et al. Projections of AIDS Morbidity and Mortality in San Francisco JAMA, March 16, 1990; 263(11): 1497 - 1501. [Abstract] [PDF]
|
|
|
|
|
|
M. H. Gail and R. Brookmeyer Projecting the Incidence of AIDS JAMA, March 16, 1990; 263(11): 1538 - 1539. [Abstract] [PDF]
|
|