American Journal of Epidemiology Vol. 130, No. 5: 925-934
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
HEMOSTATIC VARIABLES IN JAPANESE AND CAUCASIAN MEN
PLASMA FIBRINOGEN, FACTOR VIIc, FACTOR VIIIc, AND VON WILLEBRAND FACTOR AND THEIR RELATIONS TO CARDIOVASCULAR DISEASE RISK FACTORS
1Division of Epidemiology, University of Minnesota School of Public Health Minneapolis, MN
3Department of Internal Medicine, Division of Hematology/Oncology, University of Texas Health Science Center at Houston Houston, TX
4Department of Preventive Medicine and Environmental Health, University of Iowa Iowa City, IA
5Department of Epidemiology and Mass Examination, The Center for Adult Diseases Osaka, 1-3-3 Nakamichi, Higashinariku, Osaka 537, Japan
6Institute of Community Medicine, University of Tsukuba Tsukuba-shi, Ibaraki-ken 305, Japan
7Department of Public Health and Hygiene, Medical College of Oita 2-1506 Idaigaoka, Hasama-cho, Oita-gun, Oita 879-56, Japan
Reprint requests to Dr. Aaron Folsom, Division of Epidemiology, University of Minnesota School of Public Health, Stadium Gate 27,611 Beacon Street SE, Minneapolis, MN 55455
Mortality rates of coronary heart disease are much lower and hemorrhagic stroke rates are higher in Japanese than in Caucasians. To investigate whether population differences in plasma concentrations of coagulation factors are consistent with these mortality differences, the authors examined, in 1987, a total of 136 men aged 34-55 years in four different samples: rural Japanese living in Akita, Japan; urban Japanese living in Osaka, Japan; and Japanese Americans and Caucasian Americans living in Minneapolis-St. Paul, Minnesota. The mean plasma fibrinogen level in Caucasians was 290 mg/dl, which was significantly higher than that in each of the Japanese samples (223-250 mg/dl; test for difference:p < 0.001). The mean coagulation activities of factor VII and factor VIII (factor VIIc and factor VIIIc) were higher in Caucasian and Japanese Americans than in rural and urban Japanese (p < 0.01 for factor VIIc and p = 0.13 for factor VIIIc). von Willebrand factor did not differ significantly across the populations. The relations of these coagulation factors with other cardiovascular risk factors (age, body mass index (weight (kg)/height (m)2), blood pressure, serum total cholesterol, serum triglyceride, cigarette smoking, and alcohol intake) were also examined. Mean plasma fibrinogen was consistently higher in current smokers than in nonsmokers within each sample. Factor VIIc and factor VIIIc levels were positively associated with serum total cholesterol and serum triglyceride. No consistent associations were seen between von Willebrand factor and cardiovascular risk factors. After the authors controlled for these covariates, mean fibrinogen and factor VIIc levels remained significantly different, but factor VIIIc levels did not. Different levels of coagulation factors across these samples are probably attributable to differences in environmental factors, especially diet, as well as genetic differences between Caucasians and Japanese. Furthermore, the differences in plasma fibrinogen and factor VIIc levels may explain part of the difference in mortality from cardiovascular disease across these populations.
blood coagulation factors; cerebrovascular disorders; coronary disease; cross-cultural comparison; factor VII; factor VIII; fibrinogen; von Willebrand factor
2Current address: Department of Epidemiology and Mass Examination, The Center for Adult Diseases Osaka, 1-3-3 Nakamichi, Higashinanku, Osaka 537, Japan
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Associations of Plasma Fibrinogen Levels with Established Cardiovascular Disease Risk Factors, Inflammatory Markers, and Other Characteristics: Individual Participant Meta-Analysis of 154,211 Adults in 31 Prospective Studies: The Fibrinogen Studies Collaboration Am. J. Epidemiol., October 15, 2007; 166(8): 867 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Miura, H. Nakagawa, H. Ueshima, A. Okayama, S. Saitoh, J. D. Curb, B. L. Rodriguez, K. Sakata, N. Okuda, K. Yoshita, et al. Dietary Factors Related to Higher Plasma Fibrinogen Levels of Japanese-Americans in Hawaii Compared With Japanese in Japan Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1674 - 1679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Wannamethee, G. D.O. Lowe, A. G. Shaper, A. Rumley, L. Lennon, and P. H. Whincup Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease Eur. Heart J., September 1, 2005; 26(17): 1765 - 1773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Mukamal, P. P. Jadhav, R. B. D'Agostino, J. M. Massaro, M. A. Mittleman, I. Lipinska, P. A. Sutherland, T. Matheney, D. Levy, P. W.F. Wilson, et al. Alcohol Consumption and Hemostatic Factors: Analysis of the Framingham Offspring Cohort Circulation, September 18, 2001; 104(12): 1367 - 1373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakamura, G. Whitlock, N. Aoki, T. Nakashima, T. Hoshino, T. Yokoyama, S. Morioka, T. Kawamura, H. Tanaka, T. Hashimoto, et al. Japanese and Western diet and risk of idiopathic sudden deafness: a case-control study using pooled controls Int. J. Epidemiol., June 1, 2001; 30(3): 608 - 615. [Abstract] [Full Text] [PDF]
|
|