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American Journal of Epidemiology Vol. 130, No. 5: 904-910
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

research-article

LACTASE PERSISTENCE AND MILK CONSUMPTION AS DETERMINANTS OF OVARIAN CANCER RISK

DANIEL W. CRAMER

From the Department of Obstetrics and Gynecology, Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Harvard Medical School Boston, MA

Reprint requests to Dr. Daniel W. Cramer, Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115

Using published data, largely from the 1970s, the author compared ovarian cancer incidence, per capita milk consumption, and population estimates of lactase persistence (the ability to digest lactose after infancy) in 27 countries. Significant positive correlations were noted between ovarian cancer incidence, per capita milk consumption, and lactase persistence. Lactase persistence showed a stronger association than milk consumption or animal fat consumption in multiple regression models. The author speculates that toxicity from the lactose component of milk and, more specifically, galactose, the digestion of which is facilitated by lactase persistence, may provide a biologic basis for the correlation.

galactosidase; lactose; milk; ovarian neoplasms


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